200 例高压氧结合化疗治疗晚期乳腺癌临床疗效观察-第三军医大学新桥医院.docVIP

200例高压氧结合化疗治疗晚期乳腺癌临床疗效观察 李宁1,李启明1,杨明2,周宏图3,汪波4 第三军医大学新桥医院,重庆400037;2.广西桂林市解放军181医院, 桂林541002;3.江苏大学附属医院,镇江212001;4.吉林省四平市中心医院，四平136000) 　　摘要 目的 探讨高压氧结合化疗治疗晚期乳腺癌的临床疗效和毒副反应。方法　将200例晚期乳腺癌病人分为A组和B组，每组各100例患者，A组接受高压氧+CAF方案治疗，B组接受单纯CAF方案治疗，均完成2-3周期的治疗，通过X 线、B 超、CT、骨扫描、血常规、肝肾功能及临床检查，并对其进行疗效和毒副反应评价。结果　A组与B组的总缓解率有明显差异，分别为79.00 % 、57.00%（P0.05）。中位生存期A组较B长。毒副作用都能耐受，但A组毒副反应较B组轻，重度反应A组较B组少。结论　高压氧结合化疗能较好地提高治疗晚期乳腺癌疗效，并能有效地降低化疗对机体的毒副作用，值得临床推广应用。 关键词: 晚期乳腺癌；高压氧；化疗；疗效 The clinical curative effect observation on 200 Cases of intermediate and Advanced Breast Cancer cancer with hyperbaric oxygenation therapy combined with chemotherapy LI ning , LI Qi-min , YANG ming ,ZHOU Hong-tu WAN bo . (1. Hyperbaric Oxygen Therapy Center, Xinqiao Hospital, the Third Military Medical University , Chongqing 400037 , China; 2. The 181th Hospital of PLA , Gueilin 541002 ;3. The Affiliated Hospital of Jiangsu University , Zhenjiang 212001 , China; 4. Central Hospital of Siping , Siping 136000 , Giling China) Abstract : Objective　To investigate the clinical therapeutic effect of intermediate and late phase Breast Cancer with hyperbaric oxygen therapy combined with chemotherapy.Methods 200 Cases of intermediate and Advanced Breast Cancer cancer were divided into A and B groups.A group was treated by hyperbaric oxygen therapy combined with CAF scheme chemotherapy. B group was deal with CAF setup chemotherapy. All cases of chemotherapy undertakes 2-3 periodicity. The curative effect observated by X-ray, CT, and B-mode ultrasonography. Bone scan, peripheral blood cell counting, Liver and renal function were tested routinely, in order to evaluated the side effect and therapeutic results. Results The total remission rate of A and B groups get difference significantly. A group 79.00 % and B group 57.00%（P0.05）respectly. A group is better than B group in Median Survival Time. A group get better than B group in side effect and severe adverse reaction. Conclusions The goups of hyperbaric oxygen therapy combi