肺炎性肌纤维母细胞瘤的临床及病理.docVIP

肺炎性肌纤维母细胞瘤的临床及病理 张春荣，樊怿辉，谢鹏飞，施民新 江苏省南通市肿瘤医院胸外科,南通,226361 摘要 目的: 探讨肺炎性肌纤维母细胞瘤的临床及病理特点。方法: 回顾性分析3例肺炎性肌纤维母细胞瘤，3例患者均有不同程度的咳嗽及咳痰，其中一例出现痰中带血，经胸部影像学诊断为左上肺占位2例，右上肺占位1例，均行肺叶切除。结果: 本组3例均经手术完整切除肿块，无围手术期并发症，术后经病理及免疫组化检查后均符合肺炎性肌纤维母细胞瘤，3例患者SMA均为部分阳性。结论: 完整的手术切除是治疗肺炎性肌纤维母细胞的有效手段，因部分病例会出现复发及转移，故长期的随访是必要的。 关键词 肺;炎性肌纤维母细胞瘤;手术;免疫组化 Clinicopathological Features of Inflammatory Myofibroblastic Tumor of the Lung ZHANG Chunrong，FAN Yihui,XIE Pengfei，SHI Minxin. Department of Thoracic Surgery，Nantong Tumour Hospital，Jiangsu 226361 Abstract Objective: To study clinical and pathological and immunohistochemical features of inflammatory myofibroblastic tumor of the lung(IMT). Methods: Three patients affected by IMT of the lung were referred to us for surgical resection from March 2007 to October 2008. They were two males and one female with the age of 45, 59 and 52 years. Chest radiograph and computed tomography of the chest revealed two mass in the left upper lobe and one mass in the right upper lobe. All three underwent pulmonary lobectomy and local lymph nodes dissection. Results: In all our patients resections were complete. No intraoperative or perioperative medical or surgical complications occurred. Median chest-drain duration timed 3 (range 2-5) days. Immuno-histochemical reactions were in all cases positive for SMA. The most long follow-up was 54 months: no patient found tumour recurrence. Conclusions: Complete surgical resection of inflammatory myofibroblastic tumor of the lung is usually curative, but local recurrences can occur years after seemingly adequate surgical treatment. Clinical follow-up are necessary. Key Words Lung; inflammatory myofibroblastic tumor; surgical resection; immunohistochemistry 肺炎性肌纤维母细胞瘤（Inflammatory myofibroblastic tumor， IMT）是一种少见的肺部肿瘤。本文回顾性分析了自2007年3月～2008年10月收治的3例肺炎性肌纤维母细胞瘤的临床及病理特征。 资料与方法 本组3例患者，男性2例，女性1例，男性分别为45岁和59岁，女性52岁。2例男性患者有不同程度的咳嗽及咳痰，另一例女性患者出现痰中带血，量约5ml/日，无胸闷、气急等其他特殊症状。经影像学检查提示左上肺占位2例，右上肺占位1例，肿块直径分别约3.5cm、4.0cm及2.5cm，其中2例CT提示左