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Acta Physiologica Sinica, August 25, 2004, 56 (4): 539-549 WU Yong et al: The Mechanism of Insulin Sensitivity Improving Effect of Losartan in NIDDM Rats 539 Research Paper Mechanism of improving effect of losartan on insulin sensitivity of non- insulin-dependent diabetes mellitus rats 1, 2 1,* 1 1 1 3 WU Yong , OUYANG Jing-Ping , ZHOU Yun-Feng , WU Ke , ZHAO De-Hai , WEN Chong-Yuan 1Department