Restheartratereductionwithantianginaldrugs：静息心率降低抗心绞痛药物.docVIP

Reduction of resting heart rate with antianginal drugs:review and meta-analysis Michel Cucherat, Jeffrey S. Borer Supplementary material Additional figures - Detailed Forest plot (with trial results) for each agent Footnotes: CI: confidence interval; k: number of trials; n: number of patients enrolled in the k studies; WMD: weighted mean difference.  Excluded trials Trial Reason of exclusion Atenolol metoprolol Thadani (1980) [1] Not target treatment (very high dose not recommended for practice) Floris (SR 200 mg od) (1982) [2] Not randomized Crea (1990) [3] No randomized comparison with the placebo. Placebo was administered during the run-in and run-out period Diltiazem verapamil Khurmi (1987) [4] Not randomized Balasubramanian (1976) [5] Not randomized Livesley (1973) [6] Not randomized Mehta (1981) [7] Crossover authorized in case of nonresponse Pool (1982) [8] Not randomized Reference of excluded trials 1. Thadani U, et al. Comparison of five beta-adrenoreceptor antagonists with different ancillary properties during sustained twice daily therapy in angina pectoris. Am J Med 1980.68:243-50. 2. Floris B, et al. Slow release metoprolol: once daily cardioprotection for coronary heart disease. Current Therapeutic Research; 1982.31:999-1006. 3. Crea F, et al. Effects of theophylline, atenolol and their combination on myocardial ischemia in stable angina pectoris. Am J Cardiol. 1990;66:1157-62. 4. Khurmi NS, Raftery EB. A comparison of nine calcium ion antagonists and propranolol: exercise tolerance, heart rate and ST-segment changes in patients with chronic stable angina pectoris. Eur J Clin Pharmacol. 1987;32:539-48. 5. Balasubramanian V, et al. Verapamil in ischaemic heart disease--quantitative assessment by serial multistage treadmill exercise. Postgrad Med J. 1976;52:143-7. 6. Livesley B, et al. Double-blind evaluation of verapamil, propranolol, and isosorbide dinitrate against a placebo in the treatment of angina pectoris. BMJ. 1973;1:375-8. 7. M