的研究揭示一种天然免疫应答逃逸新机制.pdfVIP

Formylpeptide receptors are critical for rapid neutrophil mobilization in host SUBJECT AREAS: defense against Listeria monocytogenes INNATE IMMUNITY PATHOLOGY 1,2 2 2 2 3 4 Mingyong Liu , Keqiang Chen , Teizo Yoshimura , Ying Liu , Wanghua Gong , Aimin Wang , BACTERIA Ji-Liang Gao5, Philip M. Murphy5 Ji Ming Wang2 ANTIMICROBIALS 1Department of Spine Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China, 2Laboratory of Received Molecular Immunoregulation, Cancer and Inflammation Program, Center for Cancer Research, Frederick National Laboratory for 15 August 2012 Cancer Research, Fredrick, MD 21702, USA, 3Basic Research Program, SAIC-Frederick, Frederick, MD 21702, USA, 4Center for Orthopedics, Daping Hospital, Third Military Medical University, Chongqing 400042, China, 5Laboratory of Molecular Accepted Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA. 27 September 2012 Published 8 November 2012 Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived Correspondence and ch