凝溶胶蛋白及其生物医学作用.pdfVIP

第22卷 第3期 生命科学 Vol. 22, No. 3 2010年3月 Chinese Bulletin of Life Sciences Mar., 2010 文章编号 ：1004-0374(2010)03-0267-05 凝溶胶蛋白及其生物医学作用 李明娟，闵　锐* (第二军医大学海军医学系放射医学教研室, 上海 200433) 摘　要：gelsolin(凝溶胶蛋白)有胞浆和血清二型，分别存在于哺乳动物各类细胞和血清中。该蛋白的 基本生物功能是以钙依赖的方式通过切断、封端肌动蛋白丝，或使肌动蛋白聚集成核等方式控制肌动蛋 白的结构。大量动物实验和临床研究均表明，gelsolin 的结构、功能及调节与烧伤和急性挫伤的诊断 与治疗，以及某些炎症、肿瘤和淀粉样变等多种疾病的病理过程密切相关。作为一种急症治疗药，该 蛋白的工程化产品已在美国进行Ⅱ期临床实验。最近发现正常细胞经电离辐射后，gelsolin 的表达水平 发生显著改变，其在辐射效应中的作用和意义值得关注。 关键词：gelsolin；结构；功能；辐射损伤 中图分类号：Q51；Q518.1　　文献标识码：A Gelsolin and its biomedical functions LI Ming-juan, MIN Rui* (Division of Radiation Medicine, Department of Naval Medicine, Second Military Medical University, Shanghai 200433, China) Abstract: Gelsolin exists as a cytoplasmic and a plasma isoform, distributing in many mammal cells and plasma respectively. The gelsolin controls actin organization by severing filaments, capping filment ends and nucleat- ing actin assembly. Lots of animal experiments and clinical studies have shown that gelsolin is linked to many pathological conditions such as acute trumma and infection, inflammation, cancer and amyloidosis due to its structure and functions. As a engineering product in acute syndrome treatment, Ⅱstage clinical trail of gelsolin is going now in USA. It has been recently reported that marked alteration in expression-levels of gelsolin in cells occurs after exposed to radiation, and its role and significance are worthy of further study. Key words: gelsolin; structure; biological functions; radiation injury 1　Gelsolin的结构和调节 间有1个长的链状连接，与细胞凋亡相关的Caspase-3