EZH2与神经胶质瘤的现况研究.pdfVIP

中华临床医师杂志( 电子版)2013 年12 月第7 卷第24 期 Chin J Clinicians(Electronic Edition),December 15,2013,Vol.7,No.24 ·11685 · ·综述· EZH2 与神经胶质瘤的现况研究 王晓雪 王光明 丁跃明 潘云 【摘要】 EZH2 是一种人类基因，与果蝇zeste 基因增强子同源，属于PcG （Polycomb group ）蛋白家 族， 在多种肿瘤中高表达。目前研究认为EZH2 是肿瘤发生、发展和转移中起重要作用的转录因子抑制基 因，有望成为肿瘤靶向治疗的理想新靶点。神经胶质瘤是发生于神经外胚层的肿瘤，具有高发病率、高复 发率、高病死率和低治愈率的特点，故疗效不尽如人意。研究发现，EZH2 在神经胶质瘤中高表达；在细胞 水平的研究中，利用EZH2 基因沉默技术或者EZH2 抑制剂可以抑制神经胶质瘤细胞的增殖，因此以EZH2 为靶点的治疗方法可能为临床神经胶质瘤治疗开辟新途径。本文就 EZH2 与神经胶质瘤的研究现状作一综 述。 【关键词】 神经胶质瘤； EZH2 ； 靶点 * The research status between EZH2 and glioma WANG Xiao-xue , WANG Guang-ming, DING Yue-ming, PAN * Yun. Department of ENT, Affiliated Hospital of Dali College, Dali 671000, China Corresponding author: PAN Yun, Email: panyun09@163.com 【Abstract 】 EZH2 is a human gene, homologous with Drosophila zeste gene enhancer. It belongs to PcG (Polycomb group) protein family, and becomes the important epigenetic research object in recent years. EZH2 expresses highly in a variety of tumors such as breast cancer, prostate cancer, and glioma, and has been frequent studied currently as a transcription factor suppressor gene. Numerous studies have demonstrated that relationship between EZH2 and the occurrence, development of cancer, and EZH2 may become a new target for treating the glioma. Glioma is a cancer occurring in neuroectodermal tumor and originates from nerve stromal cells, with characteristics including high morbidity, high recurrence rate, high mortality and low cure. So the effect is not satisfactory. Many findings suggest that EZH2 is highly express in glioma, using EZH2 gene silencing technology can inhibit the proliferation of glioma cells