Bioinfo_Point生物信息学课件.pdf

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Bioinfo_Point生物信息学课件.pdf

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Xiaopeng Zhu 2011 Fall REFERENCE An Introduction to Bioinformatics Algorithms Microarrays and Expression  Analysis • Microarrays measure the activity (expression level) of the genes under varying conditions/time points • Expression level is estimated by measuring the amount of mRNA for that particular gene • A gene is active if it is being transcribed • More mRNA usually indicates more gene activity An Introduction to Bioinformatics Algorithms Microarray Data  • Microarray data are usually transformed into an intensity matrix (below) • The intensity matrix allows biologists to make correlations between diferent genes (even if they are dissimilar) and to understand how genes functions might be related Time: Time X Time Y Time Z Intensity (expression Gene 1 10 8 10 level) of gene at Gene 2 10 0 9 measured time Gene 3 4 8.6 3 Gene 4 7 8 3 Gene 5 1 2 3 A BIG TABLE Sample 1 Sample 2 Gene A 6 8 Gene B 5 7 Gene C 7 8 Gene D 4 3 Gene E 3 4 A BIG TABLE X Y Gene A 6 8 Gene B 5 7 Gene C 7 8 Gene D