大米纳米淀粉的超声法制备及载药性研究.pdfVIP

■ 捌川os巍惩删蕊CEREALFEEDINOUSTRY’-’—。’’ 大米纳米淀粉的超声法制备及载药性研究 胡爱军，张志华，郑 捷，李 倩，杨 林，吴 聪 (天津科技大学食品工程与生物技术学院，天津300457) 摘要：用超声波联合微乳液法制备大米纳米淀粉，并对大米纳米淀粉的载药性进行研究。考察了药物初始浓 度、栽药时间、载药温度对大米纳米淀粉载药量的影响，并研究了大米纳米淀粉对药物的缓释作用。结果表明，阿 霉素初始浓度为3．o 85 h后，药物释放率仅为73．9％。由此可知， mg／g。阿霉素原料2h药物释放率为99．6％，而纳米淀粉在透析8 由超声法制备的大米纳米淀粉作为药物栽体具有较好的载药性并对药物有较好的缓释作用。 关键词：超声波；纳米；大米淀粉；载药性 中图分类号：Ts231；R927．2文献标志码：A 文章编号：1003—6202f2011)08一0032一04 rices伽．ch ultr嬲。吼dandits Study蛐n蛐o prepa隋ti伽by d邝gIoadingcapability Hu Jie，Li Lin，Wu A巧un，ZhangZhihua，ZhengQian，Yang Cong ofFood and ofScienceand 300457，China) (College EngineeringBiotechnology，TianjinUniversity Technology，Tianjin ricestarchwas ultrasoniccombinedwithmicroemulsionmethod，andits ABSTRACT：Nano preparedby drugloadingcapability wasstudied．Theeffectsof initial timeand on ofnanorice adriamycinconcentration，adsorptiontemperaturedrugadsorption starchwere wellasits sustained-releaseeffect．Theresultsindicatedthatthe ofnano investigated，asdrug adriamycinadsorption ricestarch 3．O initial for30minat37℃． reachedthema豇mum(85 mmol／L adriamycin mg／g)with concentration，adsorption ofnanostarchwas to raw for After for8 releaserate 99．6％of beingdialyzedh，adriamycin only73．9％，compared adriamycin 2h．ItwasconcIudedthatnanoricestarch ultrasoundas carrierhad andsus— by drug gooddrugloadingcapability prepared tained-releaseaction． KEYWORDS：ultrasonic；nano，ricestarch；drug