高效液相色谱法检测KB和KBv200细胞裸鼠移植瘤组织中阿霉素浓度.pdf

364 Journalof 《癌症》Chinese Cancer，2008，27(4)：364—368 ·__JL ·基础研究· Cj 同效液相色谱法检测KB和KBv200细胞 裸鼠移植瘤组织中阿霉素浓度 邓文静lt2，曾昭蕾l’2， 梁永钜-，一， 戴春岭1，一， 张建业1-一， 符立梧1,2 DoxorubicinConcentrationinKBv200andKBCelI Detecting Xenografts inNudeMice byHigh—PerformanceLiquidChromatography DENG Wen—Jin91·2，ZENGZhao—Leilt2，LIANGYong—Jul，2， DAI Li—Wul，2 Jian—Yel，2。FU Chun．Lin91，2，ZHANG oneof themost used concentrationsin commonlychemotherapeuticdrugs．Drug tumortissuecan the betterlhanthatinserumdo．This predictdrug’sefficacy wastOdetectand theconcentrationofDoxinKBv200andKB study compare celI in nudemice xenografts high-performance by liquid modelsinnudemicewereestablishedwithKB (HPLC)．METHODS：Tumor KBv200 was cells(drug-sensitive)and 1．华南肿瘤学国家重点实验室． viathetailvein．TheconcentrationDoxin was injected of tumortissue 广东广州510060 detectedHPLCat and5h after by 1．3 injection，AHypersilreversed—phase 2．中山大学肿瘤防治中心 BDSC18 mmX 4．6 ID5 andmobile t