肝移植术后高血压患者的药学监护.pdfVIP

肝移植术后高血压患者的药学监护 1* 2 3 # 4 翟 颖 ，蒋 媛 ，朱立勤 ，田雪飞（1.天津中医药大学第一附属医院，天津 300193 ；2.天津市人民医院，天津 300121 ；3.天津市第一中心医院，天津 300192 ；3. 中国人民解放军第464 医院，天津 300381） 中图分类号 R95 文献标志码 A 文章编号 1672 －2124 （2014）08 －0749 －03 摘 要 目的：加强对肝移植术后高血压药物治疗的合理性和安全性。方法：阐述肝移植后高血压的特点及影响因素，确定肝移 植术后高血压药物的选择及监护要点。结果与结论：肝移植患者高血压药物的选择，应在治疗原发性高血压的基础上，充分考虑 其可能的禁忌证、不良反应及与免疫抑制药物的相互作用，进行个体化给药。目前，CCB 类药常被作为首选药使用。 关键词 肝移植；高血压；药学监护 Pharmaceutical Care for Patients with Hypertension after Undergoing Liver Transplantation 1 2 3 4 ZHAI Ying ，JIANG Yuan ，ZHU Li-qin ，TIAN Xue-fei （1. The First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine ，Tianjin 300193 ，China ；2. Tianjin Municipal People ’s Hospital ，Tianjin 300121 ，China ；3. Tianjin Municipal First Central Hospital ，Tianjin 300192 ，China ；4. No. 464 Hospital of PLA ，Tianjin 300381 ，China ） ABSTRACT OBJECTIVE ：To strengthen the rationality and safety in the antihypertensive treatment for patients after undergoing liver transplantation. METHODS ：The characteristics and influencing factors of hypertension in patients after undergoing liver trans- plantation were analyzed and the selection of antihypertensive drugs and key points in pharmaceutical care after liver transplantation were established. RESULTS CONCLUSIONS ：The selection of antihypertensive drugs in patients after undergoing liver trans- plant should be individualized in consideration of the possibility of contraindications ，adverse reactions and interactions with immu- nosuppressive drugs meanwhile taking treatment of essential hypertension as theoretic basis. Currently calcium channel blocker （CCB ）are often used as the first choice. KEYWORDS Liver transplantation ；hypertension ；Pharmaceutical care 高血压是肝移植患者常见的并发症，也是导致移植肝功 硫唑嘌呤、雷帕霉素等，此外还有抗淋巴细胞球蛋白、抗胸腺 能丧失及心血管疾病的