异丙酚抑制老年患者术毕喉罩替换气管导管时机体反应的药效学.pdfVIP

主望壁醛堂壅查垫塑笙!旦筮望鲞蔓!塑垦!也!叁些曼!塑i!!!墅堕婴坠竺!Q塑!坠!：垫!塑!：! 803 ·全身麻醉· 异丙酚抑制老年患者术毕喉罩替换气管导管 时机体反应的药效学 祝继洪 陈惠香钟泰迪 【摘要】 目的 探讨异丙酚抑制老年患者术毕喉罩替换气管导管时机体反应的药效学。方法 择期腹腔镜下拟行胆囊切除术的老年患者20例，ASAI或Ⅱ级，年龄65—70岁。术毕行喉罩替换气 管导管时，根据是否诱发机体反应，采用序贯法调节异丙酚血浆靶浓度，采用概率单位法得出异丙酚 抑制喉罩替换气管导管时机体反应的半数有效血浆靶浓度(EC。)和95％有效血浆靶浓度(EC郸)及其 95％可信区间(95％cU。结果异丙酚抑制喉罩替换气管导管时机体反应的EC。(95％CI)为2．79 老年患者术毕靶控输注异丙酚 (2．44—3．04)ve,／m]；E‰(95％CI)为3．61(3．27—4．78)pg，nd。结论 血浆靶浓度3．61vUml可满足喉罩平稳替换气管导管。 【关键词】喉面罩；插管法，气管内；二异丙酚； 药物释放系统； 剂量效应关系，药物； 老年人 of forsmooth oftrachealtubefora mask after propofol exchange laryngealairway Pharmacodynamlcs in ZHU surgeryelderlypatients Ji-hong，CHENHui-xiang，ZHONGTai-di．DepartmentofAnesthesiology， SirRunRunShaw 310016，China Hospital，ZhejiangUniversity，Hangzhou Corresponding倒n^or：ZHONGTai-di。Email：benterryted@163．corn To of forsmooth oftrachealtube 【AbstractlObjectiveinvestigatepharmacodynamicspropofol e)【change mask in i fora after elderlypatients，ASAorⅡ， laryngealairwaysurgeryelderlypatients．Me山odsTwenty 65-70 forelective wereenrolledinthis Was aged yr，scheduled laparoscopiccholecystectomy study．Anesthesia with andremifentanil．Thewere ventilatedafterthetracheaW88 inducedpropofol，atracurium patientsmechanically intubated．Anesthesiawasmaintainedwith combinedwithremifentanil．After propofol surgery，apredetermined concentrationwasachievedanda statemaintainedforatleast5rain．The propofol steady targetplasma concentrationof atwhich