法罗培南钠片剂治疗急性细菌感染的临床研究.pdfVIP

天津医药2009年lO月第37卷第lO期 耐9 法罗培南钠片剂治疗急性细菌感染的临床研究 何屏刘德梦宋诗铎崔丽英梦雅平陈天铎钟甘平杨书文 摘要目的：评价国产法罗培南钠片治疗急性细菌感染的临床疗效和安全性。方法：采用多中心、随机对照、双盲 双模拟试验，以头孢克洛片为对照药，选择急性细菌感染患者，试验组每次口服法罗培南钠200 mg．共122例；对照组 试验药物的不良反应主要为转氨酶轻度升高，但不影响治疗，未见严重不良反应。结论：国产法罗培南钠片治疗呼吸 系统和泌尿系统感染的临床疗效确切、安全性较好。 关键词头孢克洛抗菌药细菌感染多中心研究治疗结果 AClinicaIof onTreatmentofAcuteBacteriaIlnfections StudyFaropenem HE Shiduo，CUI Tianduo，ZHONG Shuwen Ping，LIUDemeng，SONG Liying，MENGYaping，CHEN Ganping，YANG and Second Medical 30021j，China ofInfectionRheumatology,TheHospitalofTianjinUniversity,Tianjin Department Abstract evaluatetheclinical and ofdomestic inthetreatmentofacutebacteri- Objective：To efficacysafety faropenem al clinicalWflgconductedtocorn- infections．Methods：A blindanddoublesimulation multicenter,randomized，double study the and of andeefaclorinthetreatmentofacutebacterialinfection．Patientsintrial m pare safetyfaropenem group efficacy 250 incontrol n l cefaclor200 times for7to10 122 weregivenfaropenemmg，and group 18 weregiven mg，3 daily days． cure Results：Theclinicalrateswere33．61％and27．12％intrailandcontrol andtheclinicaleffective groupsrespectively rateswere87．70％and wasno differenceintermsofclinicaleffectivenessbetweenthe significant 83．05％respectively．There two adversereactionrateswere7．32％intrial and3．36％incontrol ad- groups P 0．05 ．