抗高血压药发展新趋向——复方制剂的进展与临床评价.pdfVIP

·用药评价· 抗高血压药发展新趋向 复方制剂的进展与 临床评价 张石革’(北京大学第四临床医学院，北京积水潭医院，北京100035) 中图分类号R972+．4文献标识码B 文章编号1672—2124(2011)02—0102—03 摘要 目的：伴随高血压发病机制解析和抗高血压药的不断进展，新型复方制剂能够增强降压效果和减少药品不良反应，使患 者的依从性明显改善，成为当前抗高血压治疗的主流。方法：对国内、外文献进行总结分析。结果：大量的循证医学结果证实，复 方制荆显示了良好效果和安全性，在控制血压的治疗上标志着一个新里程的开始。结论：日转星移，采用优化的联合用药或复方 制荆，正成为降压新趋势和研发热点。 关键词抗高血压药；趋向；联合用药；临床评价 New Evaluationof of andClinical Developmental Drugs-Advances TendencyAntihypertensive CompoundPreparations ZHANG FourthClinicalMedical of Shi·ge+(Dept．ofPharmacy，The CollegePekingUniversity／ Jishuitan 100035，China) Beijing Hospital，Beijing of of andthe ABSTRACT the the mechanism OBJECTIVE：Accompaniedby understanding hypertension pathogenic ofthe new thatcanenhancethe unceasingdevelopmentantihypertensiVedrugs，thecompoundpreparations the andthus butreduceadve玛e reactions have antihypertensive drug significantlyimprovepatients7compliance efficacy becomethemainstreaminthe literaturebothathomeandabroad antihypertensivetherapy．METHODS：Thepertinent was resultsfromevidence-basedmedicinedemonstratedthe and analyzed．RESULTS：Considerable goodefficacysafety ofthe a ofanew in compoundpreparations，whichsignifiesbeginning stageantihypertensiVe Aslime combinationor is thenew passesby，adoptingopti