1%甲氨基阿维菌素苯甲酸盐微乳剂的研制.pdfVIP

ofAnhui 安徽农业科学。Jouzmd A鲥．Sci．2009，37(18)：8576—8578，8677 责任编辑李布青责任校对汪伟 1％甲氨基阿维菌素苯甲酸盐微乳剂的研制 张英，宋建华 (河北化工医药职业技术学院，河北石家庄050026) 摘要[目的]研制甲氨基阿维茵素苯甲酸盐(甲维盐)微乳剂。[方法]筛选甲维盐原药的溶荆，乳化赉I的种类、配比及用量，确定最佳 配方和制备工艺，并进行了新剂型的药效试验。[结果]最佳配方为甲维盐：1．66％；乙醇：2．00％；吐温80：15．9l％；十二炕基笨磺酸镁： 为一4—90℃，水的硬度对制备无影响。田问药效试验表明，药后7d的防效达90％以上。[结论】研制的甲维盐微乳荆具有成本低、性 能稳定、药效高等特．最，具有良好的开发应用前景。 关键词甲维盐；微乳荆；配方；性状；药效 中围分类号S482文献标识码A 文章编号0517—6611(2009)18—08576—03 OUthe1％EmamectinBeuteMicro-emulsion Study ZHANGal ChemicalMedicineVocational Yi喈et (Hebei Technology 050026) CoUege，Shijiazhuang，Hebei to Abstract researchaimad emamectinbenzoate Wjfhemamectinbenzoateas 【Objective]111e study micro．emulsion．[Method1 original medicine’s and oftheemulsionwerescreenedout．111e andthefea． medicine，theoriginal solvent，thetype，dosagepercentage’s prescription sible wereensured．Thecharactersand were ResultThe was of preparation pharamacodynamicsstudied．1 prescriptioncomposedemamectin heat benzoate(1．66％)，alcohol(2．00％)，Tween treatment，the the was of breakup w鹊2．16％，andcoldtreatment3．67％．the was一4—90℃．Different average percent rangeclaritytemperture rigidity had waternOeffectontheconfect．Thefieldresultsshowedthe w柏over90％after7 Themicro-emulsionhadlow efficacy day．[Conclusion1 resolution，stabilizedquality．hi曲e珩cacy。andgoodapplicationprospect． wordsEmamectin Key ben／oate：Micro．emulsion；Composition；Character；Pharmacodynamics 随着农药水基制剂的陆续开发成功并大范围的推广应 10，邢台蓝星精细化工公司产；乳化剂EC-80(脂