儿童湿疹与特异性抗体关系初探.docVIP

儿童湿疹与特异性抗体关系初探 首都医科大学附属北京世纪坛医院， [摘要】目的：初步探讨儿童湿疹与特异性抗体(slgG)水平的相关性，评估忌食不耐受食物在治疗湿疹儿童中的作用。 方法：2009年1～8月北京世纪坛医院变态反应科收治的2一14岁湿疹患儿68例，检测血液中的sIgG，初步比较儿童湿疹与slgG水平的相关性。将患儿随机分为试验组和对照组，试验组31例，忌食检测slgG阳性结果的食物，同时给予对症药物治疗。对照组3l例，只使用药物治疗而不忌食不耐受食物。2个月后观察两组的治疗效果。结果：68例湿疹患儿血清特异性[gG阳性为62人，总阳性率为91．2％。2个月后试验组有效率87．1％，对照组有效率32．25％，两组之间具有明显统计学差异(P0．01)。结论：儿童湿疹患者的体内slgt；阳性率较高，提示湿疹症状可能与食物不耐受有关。湿疹患儿忌食不耐受食物可以增强药物治疗 的效果，同时联合蛇胆苦柏爽肤洗液涂抹。 Childhood Eczema and Serum IgG ZHUANG Yah，WANG Xue—yah，SHI Hai—yun，ZHANG Ming，HE Huan (Sh弛口n Hospital，Be驴ng Medical University，Be彬ng 1 00038，China) [Abstract] Objective：To discuss the relationship between child eczema and food—specific IgG antibodies (slgG)，and to evaluate the effect of favoiding the intolerant food on the treatment of eczema．Method：Food—SIgG in blood serum of 68 children(aged rang 2-14 years)with eczema were examinated．All patients were randomly allocated into 2 group：cases-group and and controls—group，received avoiding the intolerant food plus pharmacotherapy(n=3 1) and pharmacotherapy alone(n=3 1)，respectively．The effect of two group was evaluated after 2 months．Result： Positive food—slgG in serum was detected in 62 patients．with the positive percentage of 91．2％．The effective rate of cases group was 87．10％after the 2nd month，while 32．25％of controls group．There was a significant difference between two groups(P0．01)．Conclusion：Hight positive percentage of food—slgG was found in patients suffering from eczema，indicating a possible correlation of eczema symptom and food-intol6ranee．Avoiding of intolerant food had an enhanced effect for pharmacotherapy to child eczema． [Key words] childhood eczema；sIgG；avoid certain food 具有特应性体质的人可被变应原致敏后引起一系列的病理生理过程。‘临床可引起湿疹、荨麻疹等皮肤疾病或其他器官的病变。一般认为，0～2岁婴幼儿湿疹是sIgE介导的I型变态反应，婴幼儿湿疹多由鸡蛋牛奶等食物过敏引起已被儿科医师所公认，但3一14岁儿童湿疹的临床报道并不多见，本研究旨在观察儿童湿疹与血液中slgG的关系及忌食slgG检测阳性的食物后儿童湿疹的治疗效果。 1资料与方法 1．1病例选择2009年1月至8月于北京世纪坛医院变态反应科就诊的3一14岁儿童，符合湿疹诊断标准，年龄在3岁以上，14岁以下者，能坚持门诊治疗8周以上者。有下列情况者均为排除病例：①服用或外 用抗组胺类或激素类药物；②不能坚持者。改用其他药物患者，应按无效病例处理。有下列情况者均