松龄血脉康胶囊对原发性高血压患者动态血压相关指标的影响：随机单盲对照试验_医学论文.docVIP

松龄血脉康胶囊对原发性高血压患者动态血压相关指标的影响：随机单盲对照试验_医学论文 松龄血脉康胶囊对原发性高血压患者动态血压相关指标的影响：随机单盲对照试验_医学论文 作者：付莉, 毛振兴, 王静, 张静, 郑太蓉, 王胜莲 【摘要】 在联合使用钙离子拮抗剂及血管紧张素受体拮抗剂的基础上加用中成药，观察其对24 h动态血压监测相关指标的影响，评价降压效应及降压稳定性。方法：将70例初诊为原发性高血压或有原发性高血压病史但服药无规律或未正规服药，就诊时血压分级为2～3级的患者随机分为常规降压组（常规组）和常规降压加松龄血脉康组（松龄血脉康组），每组各35例。常规组口服左旋氨氯地平片2.5 mg，联合替米沙坦片40 mg，1次/d。松龄血脉康组在常规组治疗的基础上加服松龄血脉康胶囊1.5 g，3次/d。疗程均为2周。治疗前后分别进行24 h动态血压监测，并进行谷峰比值、平滑指数等指标的计算和血压晨峰的判定。结果：两组治疗后24 h、白昼及夜间平均收缩压和收缩压负荷值均低于治疗前（P＜0.05），常规降压加松龄血脉康的降压效果优于常规降压（P＜0.05）。常规降压加松龄血脉康能降低舒张压，而常规降压对舒张压的影响不明显。常规降压加松龄血脉康降压的同时能减慢心率，常规降压则对心率影响不明显。松龄血脉康组谷峰比值高于常规降压组（P＜0.05），两组平滑指数比较，差异无统计学意义。两组治疗后血压晨峰现象均得到改善（P＜0.05），常规降压加松龄血脉康对血压晨峰现象的改善程度优于常规降压（P＜0.05）。结论：在联合使用左旋氨氯地平片和替米沙坦片的基础上加用中成药松龄血脉康胶囊，能更有效地降低心率和血压，特别是收缩压和收缩压负荷值，降压效应的平稳性更高，维持时间更长，还能有效控制血压晨峰现象。 【关键词】 高血压 血压测定 随机对照试验 单盲法 Objective: To explore the effects of Western medicine including Ca2+ channel antagonist and angiotensinndexes derived from 24hour ambulatory blood pressure monitoring (ABPM), and to evaluate the effects and stability of SXC in lowering blood pressure. Methods: Seventy patients with essential hypertension of grade 2 or grade 3 were randomly assigned to routine group and SXC group. There were 35 cases in each group. The patients in the routine group were administered with 2.5 mg levoamlodipine and 40 mg telmisartan once daily, and 1.5 g SXC was administered orally to the patients in the SXC group three times daily besides levoamlodipine and telmisartan treatment. They were all treated for two weeks. Twentyfourhour ABPM, trough to peak ratio and smoothness index were measured before and after the treatment. Results: Twentyfourhour, day and night average systolic blood pressure (SBP) and 24hour, day and night SBP load in the two groups were lowered as compared with before treatment (P＜0.05). The effects of Western medicine combined with SXC on blood pressure depression were better than those of Western medicine (P＜0.05). Western medicine combined with SXC had a significant influence on diastolic