乳腺波谱2010.12.pptVIP

乳腺1H-MRS Overview MRS using different compounds from body magnetic resonance frequency in a strong magnetic field differences, reflect some biochemical substances in the body content of different region. MRS 利用不同化合物自身磁性在强磁场下共振频率的差异,反映一些生化物质在体内不同区域的含量 MRS is a noninvasive study living organ, tissue metabolism, quantitative analysis of biochemical changes in the methods and compounds. MRS是无创性的研究活体器官、组织代谢、生化变化及化合物定量分析的方法。 Can reflect the metabolic situation of organization at the molecular level. 能在分子水平反映组织的代谢情况。 MRS is an important aspect of quantitative analysis of metabolites. MRS的一个重要方面是可以对代谢产物进行定量分析。 Can make use of peak height (representing the resonance signal intensity) and width (on behalf of the resonance frequency) calculated the area under the peak.可利用波峰的高度（代表共振信号强度）和宽度（代表共振频率）计算波峰下面积。 The area under the metabolite peak measured with the proportional content of the metabolites. 各代谢产物的波峰下面积与所测的代谢产物的含量成正比。 MRS including both 1p-MRS and 1H-MRS. 磁共振波谱包括磷谱和氢质子谱两种。 1H-Spectrum Peak Cho（胆碱）：choline Peak （波峰）at 3.2ppm Choline in cell membrane synthesis and degradation, and membrane phospholipid metabolism, and is the neurotransmitter acetylcholine precursors.胆碱参与细胞膜的合成和降解，与细胞膜磷脂代谢有关，并且是神经递质乙酰胆碱的前体。 Spectrum detected is not fixed within the choline in the cell membrane, but the film conversion process in the water-soluble components, mainly soluble choline compounds。波谱检测到的不是固定在细胞膜内的胆碱，而是膜转换过程中的水溶性成分，主要是可溶解的胆碱化合物。 Cho wave increased explain update to speed up the cell membrane, cell density, usually due to tumor cell proliferation. Cho波增高说明细胞膜更新加快、细胞密度大，通常为肿瘤细胞增殖所致。 breast 1H-MRS measurements Cho of tissue main content. 乳腺1H-MRS主要测量组织内Cho的含量。 Cho and its metabolites was determined from the mammary epithelial cell metabolism, mainly involved in membrane transport and diffusion functions. Cho及其代谢物的含量决定于乳腺上皮细胞的代谢水平，主要是参与细胞膜运输及扩散功能。 As the active metabolite of free Cho levels in normal tissues in the lower, Cho concentration reflects increased membra