Ezrin和EZH2与肿瘤关系的研究进展.pdfVIP

窑综 述 窑 中国医药导报 2015年 1月第 12卷第2期 Ezrin和EZH2 与肿瘤关系的研究进展 李宇实 李正民 郝 玢 王玉学银 哈尔滨医科大学第三临床医学院骨外科袁黑龙江哈尔滨 150040 [摘要] 近年来随着分子生物学的高速发展以及对于肿瘤方面的不断深入研究袁越来越多的与肿瘤相关联的蛋白 和基因被人们所发现袁并受到广泛的重视袁而且也将这些蛋白基因高度应用于医学研究中遥在目前众多的研究结 果中Ezrin和EZH2是两个被深入研究的基因袁但是目前对于Ezrin和EZH2的研究结论并不十分全面和具体袁还 存在一些其他因素遥 因此对于Ezrin和EZH2更为深入的研究是十分必要的袁本文就Ezrin和EZH2的结构尧功能 与肿瘤的相关性做一简要综述便于日后进一步研究遥 [关键词] 肿瘤曰Ezrin曰EZH2曰研究 [中图分类号] R730 [文献标识码]A [文章编号] 1673-7210渊2015冤01渊b冤-0160-04 ResearchprogressofEzrinandEZH2 andits relationshipwithtumor LI Yushi LI Zhengmin HAO Bin WANG Yuxue银 Department of Orthopedic Surgery, the Third Clinical School of Harbin Medical University, Heilongjiang Province, Harbin 150040,China [Abstract]In recent years, with the rapid development of molecular biology and deepening of research for tumor, more and more protein and gene associatedwith cancer were found, and has been widely attention, but also the protein gene is highly used in medical research. In numerous results in the study of Ezrin and EZH2 is considered to be two in- depth study of genes, but the conclusion on the study of Ezrin and EZH2 is not very comprehensive and specific, there are still someotherfactors. Sothe more in-depthresearch on Ezrin and EZH2 is necessary, in this paper, the structure of Ezrin andEZH2,function and correlation oftumor arereviewed tofacilitatefurther research inthefuture. [Keywords]Tumor; Ezrin;EZH2; Research 近年来袁随着医学分子生物学的不断研究与发 有异常表达袁并且与促肿瘤转移有密切联系遥 早在 [1] 展袁人们逐渐认识到恶性肿瘤的发生是由于肿瘤细胞 1983年Bretsher 首先在鸡的小肠上皮细胞刷状缘中 [2] 基因的一系列变化