二苯乙烯苷对痴呆小鼠学习记忆及自由基代谢的影响_楚晋.pdfVIP

2003 9 11 C in J Re abil T eory Practice, November 2003, Vol 9, No. 11 # 643 # ## * 楚晋 叶翠飞 李林 [ ] ( TSG) B-( AD) AB1-40, TSG , Morris ( MDA) ( MAO-B) (T-AOC) , ( P 0105) , MDA MAO-B ( P 01 01) ; TSG ( P 01 01) , MDA ( P 01 01) MAO-B ( P 01 05) , (T-AOC) ( P 01 01) T SG , , AD [ ] ( TSG) ;B-; ; ; Effects of stilbene-glycoside on learning and memory function and free radicals metabolism in dementia model mice CH U Jin, YE Cui- f ei , LI L in . Dep ar tment of Phar macology , X uanw u H o p ital of Cap ital Univ er ity of Medical Science, Beij ing K ey L aboratory f or Br ain A ging , Beij ing 100053, China [Abstract] Objective To observe t e effect of 2, 3, 5, 4.-tetra ydroxy stilbene-2-B-D-glycoside(TSG) on learning and memory abili- ty and free radicals metabolism in dementia model mice induced by B-amyloid ( AB) . Methods AB1-40 was given to t e rig t lateral ventricle in t e model group, and t e T SG ad been administered to t e t erapy group for 8 weeks by gastrogavage.All t e mice of different groups w ere tested w it Morris water maze and step-t roug test . T en t e mice were killed and bioc emical assays of neurol MDA, MAO-B, T- AOC w ere performed. Results T e model mice s ow ed worse ability in learning and memory compared w it control mice. T e MDA co- tent , MAO-B activity in t e cortical increased in model mice compared w it normal control; TSG reduced t e MDA content, MAO-B ac- tivity, and increased T-AOC activity. Conclusion T SG can improve t e learning and memory ability of model mice, decrease peroxidation level of brain, and increase antioxidation ability of brain, w ic suggest t at TSG may ave a promising application in treatment of demen- tia disease suc as AD. [Key words] 2, 3, 5, 4.-tetra ydroxy st