2008 李春光 Modeling and Analyzing Biological Oscillations in Molecular Networks.pdf

I N V I T E D P A P E R Modeling and Analyzing Biological Oscillations in Molecular Networks Techniques based on dynamical and control theories, for representing the synchronization of signals between cells, can be used to reduce the complexity of modeling biological systems. By Ruiqi Wang, Chunguang Li, Luonan Chen, Senior Member IEEE , and Kazuyuki Aihara ABSTRACT | One of the major challenges for postgenomic cooperative behaviors for a population of bio-oscillators. biology is to understand how genes, proteins, and small mole- Finally, as an illustrative example, a synthetic multicellular cules dynamically interact to form molecular networks which system is designed to show how synchronization is effectively facilitate sophisticated biological functions. In this paper, we achieved and how dynamics of individual cells is efficiently present a survey on recent developments on modelling mole- controlled. Some recent developments and perspectives of cular networks and analyzing synchronization of bio-oscillators analysis on biological oscillations in future are also discussed. in multicellular systems from the viewpoint of systems biology. Attention will be focused on deriving general theoretical results KEYWORDS | Cellular communication; dynamical control; gene to understand the dynamical behaviors of biological systems regulatory network; master equation; molecular network; based on nonlinear dynamical and control theory. Specifically, noise; oscillator; switch; synchronization we first describe the stochastic and deterministic approaches to model molecular networks and give a brief comparison I. INTRODUCTION between them. Then, we explain how to construct a molecular network, in particular, a g