L_肉碱对肥胖大鼠体脂含量及肥胖基因表达产物的影响.pdfVIP

L - 肉碱对肥胖大鼠体脂含量及肥胖基因表达产物的影响 1 1 1 2 2 1 1 1 1 陈世伟 　张 　丁 　刘翠娥 　费炳洪 　苏 　瓒 　张 　杰 　王海玉 　孟 　光 　张 　焱 ( 1 河南省卫生防疫站 ,河南 　郑州 　450003 ;2 . 郑州大学第一附属医院 ,河南 　郑州 　450052) ( ) 摘 　要 :为探讨 L - 肉碱对肥胖大鼠体重 、体脂 、胰岛素及肥胖基因表达产物 瘦素 等水平的影响 , 以高脂饲料诱导大鼠肥胖模型 ,将肥胖模型鼠随机分为 4 组 :对照组与 125 、250 、500 mgkg BW 3 个 剂量的L - 肉碱组 ,每天 1 次经 口给予 ,共 6 周 。观察大鼠体重 、睾丸 + 肾脂肪垫重量 、胰岛素 ( ) ( ) INS 及瘦素 Leptin 水平等 的变化 。结果显示 3 个 肉碱 组 的体重均低 于对 照组 , 250 与 500 mgkg BW组的睾丸 + 肾脂肪垫重量 、胰岛素和瘦素显著低于对照组 ( P 005) ,提示 L - 肉碱 具有抑制肥胖大鼠肥胖的作用 。 关键词 : 肉碱 ;肥胖症 ;胰岛素 Effect of Lcarnitine on fat content of body and expressive product of ob gene in obese rats Chen Shiwei , et al . ( Health and Antiepidemic Station of Henan Province , Henan Zhengzhou 450003 , China) Abstract : To investigate the effects of oral L carnitine (LC) supplement on body weight , fat content , and se rum levels of insulin and leptin in obese rats , male Wistar obese rats , induced by high fat diet , were randomly divided into four group s and fed LC of 0 , 125 , 250 , 500 (mgkg BW) respectively for six weeks. At the end of the experiment , body weight of the rats , fat pad around kidneys and testes and serum levels of insulin and leptin were measured . The results showed that the body weight of rats in all LC supplementation group s de creased significantly compared with that in the control group ( P 005) . Fat pads and levels of insulin and leptin of rat in 250 mgkg BW and 500 mgkg BW group s were lower than those of rats in control group ( P 005) . It was concluded that LC may increase consumption of energy , decrea