系膜增生性肾小球肾炎与MMP-2、TIMP-2的关系及中医药研究进展.pdfVIP

浙江中医药大学学报20 14 年 11 月第38 卷第 11 期 系膜增生性肾小球肾炎 与MMP-2、TIMP-2 的关系及中医药研究进展 J O U R N A L O F Z H E J I A 胡营杰 任现志 N G 南京中医药大学 南京 210029 C H 摘要：[ 目的]探究基质金属蛋白酶及其组织抑制剂MMP-2 、TIMP-2 的失衡与肾小球的硬化的关系及中医药方面的研究进展。[方法]通过查阅相 I N 关文献，从MMP-2 、TIMP-2 的生物学特性及作用机制、与系膜增生性肾小球肾炎的关系、中医药对其表达的影响等方面加以论述，指出现阶段 E S E 中医药研究方面的进展。[结果]MMP-2 、TIMP-2 在肾小球肾炎的疾病发展的不同病理阶段（本文主要阐述增生硬化阶段）的表达不同，中医药能 M 够在不同的病理阶段上调或下调其表达，延缓疾病向肾小球硬化的进展。[结论] 中医药在系膜增生性肾小球肾炎方向的应用为中医药的发展提供 E D 了依据，同时为系膜增生性肾小球肾炎的治疗提供新的方向。 I C A 关键词：系膜增生性肾小球肾炎；MMP-2 ；TIMP-2 ；中医药；进展 L U 中图分类号：R552 文献标识码：A 文章编号：1005-5509（2014 ）11-1342-04 N I Correlation of MMP -2 and TIMP -2 with Mesangial Proliferative Glomerulo -nephritis and Its Research Progress in Traditional Chinese V E R Medicine Hu Yingjie, Ren Xianzhi Nanjing University of Chinese Medicine, Jiangsu(210029), China S I T Abstract: [Objective] To explore both the correlation of matrix metalloproteinase and the imbalance of its tissue inhibitors-MMP-2 and TIMP-2 with Y glomerulosclerosis and its research progress in traditional Chinese medicine. [Methods] We generalized the research progress in traditional Chinese medicine V O from such aspects as the biological properties of MMP -2 and TMIP -2 and their mechanisms, their relationship with mesangial proliferative L . glomerulonephritis and effects of traditional Chinese medicine on their expression by searching the relevant literatures. [Results] Expressions of MMP-2 3 8 and TIMP-2 vary in different pathological stages(hyperplasia and sclerosis stage here) of glomerulonephritis, and traditional Chinese herbs could adjust their N O expressions in different stages. Traditional Chinese he