Wnt信号通路在乳腺癌中的作用.pdfVIP

# 210# ( J Sh anx iM ed Un iv) 2010 3, 41 ( 3) W n t , , , , , (, 100050) : W nt B2caten in cyc linD 1c2m yc SP 119 , 72 40 B2caten incyc linD 1c2my c, PCR 44B2ca ten in 3, SP B2caten in 4 0 B2caten in , cyc linD 1 c2m yc B2ca ten in , ( 7 8. 15% vs 44. 44% , P 0. 0 1), cyc linD 1c2my c ( 57. 98% vs 33. 33% 56. 30% vs 27. 78% , P 0. 01) B2caten in cyc linD 1, c2m ycB2 caten in cyc linD 1 , c2m yc44 B2 ca ten in 3, B2 ca ten in 77. 30% B2caten in , cyc linD 1 B2caten in cy clinD1c2m yc B2 ca ten in B2 ca ten in , : W nt B2caten in cy clinD 1 c2m yc : R 737. 9 : A : 1007- 6611( 2010) 03- 0210- 04 Sign ificance ofW n t signa ling in br ea st car c inom a HE Y an2jiao, LIU Zh ao2xia, Q IAO Ch ao, XU M iao2sh en g, YU Jin, LI Guang ( DeptofPathology, Beijing TiantanHospital, Capital Medical University, Beijing 100050, China) Ab str act: bjective To investigate th e mu tation and expression of B2cat en in and the express ion of cyc linD1, c2m yc in breast carcin o2 m a. Methods Th e expression of B2caten in, cy clinD1, c2m yc w as de tected u sing mi mun oh istoch em istry in 119 cases of breast carcin o2 m a tissu es, 72 cases ofbreast cystic hyp erp lasia tissu es and 40 cases of n orm a l breast tissu es. Th e re lation sh ip s of B2caten in, cy clinD 1, c2m yc expression w ith th e c lin icop athological features of breast carc inom as w ere an alyzed. Gen e muta tion of B2 ca ten in ( exon 3) in 44 cases