EGF多态性与HBV进展相关.pdfVIP

Clinical and Experimental Immunology ORIGINAL ARTICLE doi:10.1111/j.1365-2249.2011.04497.x Carriage of the EGF rs4444903 AG functional polymorphism cei_4497 296..302 associates with disease progression in chronic HBV infection S. Cmet,* C. Fabris,† G. Fattovich,‡ Summary E. Falleti,* D. Bitetto,† A. Cussigh,* E. Fontanini,* E. Fornasiere,† Because epidermal growth factor (EGF) up-regulation is characteristic of the M. Pirisi§,¶ and P. Toniutto† cirrhotic liver, we hypothesised that the EGF rs4444903 A G functional † polymorphism might be associated with a worse disease course in patients *Laboratory Medicine, Medical Liver Transplant Unit, Internal Medicine, Department of Medical with chronic HBV infection. To verify this hypothesis, 170 HBV-positive Sciences, Clinical and Experimental, University of patients (125 males) with a median age of 52 years were studied. Sixty-two of Udine, Udine, ‡Department of Surgical and these patients were followed longitudinally for a median time of 21 years. Gastroenterological Sciences, University of Genotyping for the EGF rs4444903 A G polymorphism was performed by Verona, Verona, §Department of Clinical and the polymerase chain reaction-based restriction fragment length polymor- Experimental Medicine, and ¶Interdisciplinary phism assay. In the cross-sectional study, the EGF rs4444903 A G poly- Research Center of Autoimmune Diseases morphism genotypic frequencies significantly differed between transplant (IRCAD), Un