甲状腺激素在心脏重塑中的前景.pptxVIP

New insights into the role of thyroid hormone in cardiacremodeling: time to reconsider?;Backgrounds;3.nature’s paradigms of tissue remodeling/regeneration---- 两栖动物变态;4.TH has attracted little attention in the context of cardiac disease;content;一 . Cardiac remodeling;二. Thyroid hormone ;甲状腺激素;Two TR genes, α and β, encode four T3-binding receptor isoforms (α1, β1, β2, and β3); The distinct function of TR isoforms has been identi?ed;3.TRα 1 function in heart ;a fetal transcriptional gene re-programming;TRa1: a molecular switch to the fetal phenotype;mechanisms of altered TRa1 expression？;closely associated with cardiac dysfunction in animals and patients with heart failure;Key mediators of pathological growth ： ERK kinase and mTOR ;4 TH：mechanisms of action;三. TH signaling in cardiac remodeling;Maturation of the myocardium depends on increasing TH signaling;2. TH signaling alterations in the course of post-ischemic remodeling;TH signaling can be implicated in the response to ischemia both in normal and pathological myocardium.;4.TH signaling in the non-ischemic pathological heart;四 . TH ‘s function in the cardiac remodeling ;Regulating the expression of contractice proteins; TH optimizes cardiac geometry; TH controls collagen synthesis; TH induces angiogenesis;2.TH increases tolerance of the myocardium to ischemia/reperfusion injury;TH mimics preconditioning effect;TH心脏保护功能机制;PKC: a potential key player;氧化还原调控信号;TH 诱导线粒体生物合成;3.TH can convert pathological to physiological hypertrophy;T4 处理压力增大，但是不会引起腔和心肌的僵硬，也不会发展成为心肌衰竭，胶原蛋白浓度降低，;4. TH and signaling of the unloaded heart;5. Clinical implications: protection versus function;五. Clinical translation of TH effects; 短期T3治疗 心肌缺血和非心肌缺血膨胀综合症; 中期T4治疗 ; 低剂量T4 治疗 难治性心率衰竭和正常甲状腺病态综合症;2. TH treatment in the setting of controlled ischemia–reperfusion;Study 2;conclusion