HBeAg阴性慢性乙型肝炎患者血清病毒载量与肝组织学改变的关系.pdfVIP

·184· ．论著 HBeAg阴性慢性乙型肝炎患者血清病毒载量 与肝组织学改变的关系 陆传统，周文红，胡爱荣 DNA水平与肝组织损害的关系。 【摘要】 目的探讨HBeAg阴性慢性乙型肝炎患者血清HBV 方法 以HBeAg阳性慢性乙型肝炎病例为对照，回顾分析HBeAg阴性慢性乙型肝炎患者血清HBV DNA DNA水平与肝组织病理炎症分级、纤维化分期之间的关系。结果HBeAg阴性与阳性组HBV 平均含量分别为(5．38±1．27)logl0拷贝／ml和(6．80±1．18)logl0拷贝／ml，差异有统计学意义(P 0．01)。与HBeAg阳性组比较，HBeAg阴性组肝组织炎症分级及纤维化分期较高(P0．01)。HBeAg 阴性患者HBVDNA水平与肝组织炎症分级及纤维化分期呈正相关(P0．01)。结论HBeAg阴性 慢性乙型肝炎病毒载量低，乙肝病毒载量与肝损害呈正相关。 【主题词】肝炎，乙型，慢性；肝炎e抗原，乙型；DNA；肝炎病毒属；组织病理学 loadsandthe ofliver featuresin onthe betweenHBVviral Study relationship changes pathological with chronic B LU Chuan·tong，ZHOUWen-hong，HU patientsHBeAg-negativehepatitis Ai-rong． Disease 3 NingboInfectiousHospiatl，Zhejiang15010，China Correspondingauthor：LUChuan—tong，Email：chuantong．1u@gmail．com To the betweenserumHBVDNAloadsandliver 【Abstract】objectiveinvestigaterelationship in with chronic B．MethodsThe the hepatitis histologydamage patientsHBeAg-negative retrospective was 514 weredividedintotwo tothe statusandthe studyperformed．Thepatients groupsaccordingHBeAg wasascontr01．The HBVDNA loads，live HBeAgpositivegroup relationshipamong histological inflammationandfibrosis was TheHBVDNAloadsin grades stagesanalyzed．Results HBeAg·negative and 0 and(6．80±1．1 groupHBeAg—positivegroupwere(5．38±1．27)l091copies／ml 8)loglOeopies／ml inflammationandfibrosis oflivertissuesin respectively(P0．001)．Thegr