乳腺癌基因环境交互作用的研究进展.pdfVIP

558 　　肿瘤2011 年6 月第31 卷第6 期　Tumor Vol. 31, J une, 2011 DOI:10.3781/j .issn.1000-7431.2011.06.017 Review ·综述 乳腺癌基 因环境交互作用的研究进展 1 2 3 1, 2 江军仪 ，项永兵 ，陶梦华 ，徐望红 1. 复旦大学公共卫生学院流行病学教研室，教育部公共卫生安全重点实验室，上海200032 ；2 . 上海市肿瘤研究所 流行病学研究室，上海200032 ；3. 布法罗大学公共卫生与卫生事业学院社会与预防医学系，纽约142 14 [摘要]　乳腺癌是女性最常见的恶性肿瘤之一。基因-环境交互作用 （gene-environment interaction ，GEI ）在乳腺 癌发病中的作用一直是人们关注的焦点，早期的研究采用候选基因方法，主要关注代谢酶基因，DNA 修复基因和 凋亡基因等。近年来，乳腺癌全基因组关联研究 （genome-wide association study, GWA S ）发现了多个乳腺癌易感 基因及位点，为乳腺癌 GEI 研究提供了广阔的发展前景，并带来了极大的挑战。本文就 目前乳腺癌GEI 的研究现 状及进展进行综述，以揭示进一步研究的趋势和方向。 [关键词]　乳腺肿瘤；危险因素；基因-环境交互作用 1 [中图分类号]　R737.9 [文献标志码] A [文章编号]　 000-7431(2011)06-558-07 Advances in research of gene-environment interactions in breast cancer 1 2 3 1, 2 JIANG Jun-yi , XIANG Yong-bing , TAO Meng-hua , XU Wang-hong 1. Department of Epidemiology, School of Public Health, Fudan University; Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Shanghai 200032, China; 2. Department of Epidemiology, Shanghai Cancer Institute, Shanghai 200032, China; 3. Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, New York 14214, USA [A BSTRA CT]　 Breast cancer is one of the most frequently diagnosed cancers in women. It has been increasingly recognized that breast cancer is a result of interplays between different exposures and host susceptibilities. The study of gene-environment interactions (GEI) has been confined to candidate gene approach which is mainly involving genes related to metabolism, DNA repair, cell apoptosis, etc. Recent genome-wide association studies are identifying novel susceptibility genes of breast can