胺碘酮在COPD急性加重期顽固性窦性心动过速患者中的作用_医学论文.docVIP

胺碘酮在COPD急性加重期顽固性窦性心动过速患者中的作用_医学论文 胺碘酮在COPD急性加重期顽固性窦性心动过速患者中的作用_医学论文 作者：邓节喜，张俊松，邱跃灵，窦燕，陈劲松，孙婷婷，郭寿贵，林庚海 【关键词】 ,肺疾病,慢性阻塞性,急性加重期；胺碘酮；心动过速,窦性 　【Abstract】 AIM: To observe the effects of amiodarone on persistent sinus tachycardia during an acute exacerbation of chronic obstructive pulmonary disease(COPD). METHODS: The COPD patients in an acute exacerbation were divided into 3 groups according to their heart rate (HR) after 2 h basic treatment, including proper oxygen administration, antiinfection therapy, acidbase and electrolyte rebalance, eliminating phlegm, spasmolysis and antiasthma. Group A (n=112) was intravenously administrated with 150 mg amiodarone, and their HR was above 120 beats/min(BPM) after basic treatment. Group B included 79 patients with heart rate above 120 BPM after basic treatment and wasnt administrated with amiodarone. Group C included 121 patients, whose HR was below 120 BPM after basic treatment. The parameters of HR,breath rate (BR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and the main parameters of their bloodgas analysis of artery blood were observed at 2 and 3 h after basic treatment in group B and C, and at the moments before and after amiodarone injection in group A. RESULTS: HR and BR of patients in group A were decreased significantly （142.6±18.3 vs 97.4±17.4, 35.2±7.6 vs 23.8±5.4, P＜0.05）after amiodarone injection. Blood pressure didnt change. The parameters of bloodgas analysis of their artery blood after injection were significantly better than those befor injection in group A (P＜0.05), even better than those in group B and group C (P＜0.05). CONCLUSION: The intravenous injection of amiodarone can be used efficiently and safely in patients with persistent sinus tachycardia during an acute exacerbation of COPD. 【Keywords】 pulmonary disease, chronic obstructive, acute exacerbation stage Amiodarone tachycardia, sinus 【摘要】 目的： 探讨静脉注射胺碘酮在慢性阻塞性肺病（COPD）急性加重期顽固窦性心动过速抢救中的疗效及安全性. 方法： COPD急性加重期患者312例，经合理氧疗、抗感染、纠正酸碱失衡及电解质紊乱、解痉