组织工程技术治疗周围神经缺损的研究进展.pdfVIP

1310 Chinese Journal of Reparative and Reconstructive Surgery, November 2010, Vol. 24, No.11 · · 组织工程技术治疗周围神经缺损的研究进展 杨亚东 薄占东 【摘  要】    目的 对近年采用组织工程技术治疗周围神经缺损相关研究进行综述。  方法 查阅近年来国内外 关于采用组织工程技术治疗周围神经缺损的基础研究和临床应用文献，并进行综合分析。  结果 采用缓释技术局部应 用神经营养因子，其方法主要有分子生物学技术、聚乳酸- 聚羟基乙酸共聚物微球、聚磷酸酯微球等。这类技术主要是将 神经营养因子适当保护后与导管材料混合加工成型，然后将其嵌合于神经导管壁，这种管壁本身可通过降解缓慢释放神 经营养因子；种子细胞作为组织工程活性成分的主要来源，对于组织工程产品的修复重建效果举足轻重，雪旺细胞的神经 导管可修复较长距离的神经缺损，神经再生质量也得到改善；神经支架材料包括天然可降解材料和合成可降解材料两大 类，神经支架通常采用管状结构，其性能将直接影响神经修复效果。  结论 随着组织工程研究的不断深入，组织工程治 疗周围神经缺损已经取得明显进步。 【关键词】 组织工程神经 神经营养因子 种子细胞 神经支架 中图分类号： R622.3 R651.3 文献标志码：A PROGRESS OF PERIPHERAL NERVE DEFECT TREATMENT WITH TISSUE ENGINEERING/YANG Yadong, BO Zhandong. Department of Orthopaedics and Traumatology, First Affiliated Hospital of Guangxi Medical University, Nanning Guangxi, 530021, P.R.China. Corresponding author: BO Zhandong, E-mail: zdb71718@163.com 【Abstract 】    Objective To review new progress of related research of peri pheral nerve defect treatment with tissue engineering in recent years. Methods Domestic and internationl l iterature concerning peri pheral nerve defect treatment with tissue engineering was reviewed and analyzed. Results Releasing neurotrophic factors with sustained release technology included molecular biology techniques, poly (lactic-co-glycol ic acid) microspheres, and polyphosphate microspheres. The mixture of neurotrophic factors and ductus was implanted to the neural tube wall which could be degraded then releasing factors slowly. Seed cells which were the major source of active ingredients played an important role in the repair and reconstruction of tissue engineering products. The neural tube of Schwann cells made long nerve repair and the qua