PATHOPHYSIOLOGY课件.PPTVIP

PATHOPHYSIOLOGY Wang Hua-dong Department of Pathophysiology, Jinan University 2015.3.2-3.16 Chapter 1 Concept of Disease Introduction to pathophysiology A general introduction to disease Disease etiology Pathogenesis Outcome of disease 1. What is pathophysiology? The word root “patho” is derived from the Greek word pathos, means suffering; Greek word root “logos” means system of formal study; “Physio” pertains to functions of organisms. Pathophysiology is the systemic study of the metabolic and functional changes in cells, tissues, and organs induced by disease. What is pathophysiology? Host Structure Function Metabolism Normal Anatomy Physiology Histology Biochemistry Abnormal Pathology Pathophysiology PATHOLOGY: Study of structural changes associated with disease. It can be applied to clinical setting. PATHOPHYSIOLOGY: Study of how pathological changes (and related compensatory mechanisms) result in functional limitations and metabolic abnormalities. Knowledge of cellular biology as well as anatomy, biochemistry, physiology, immunology and the various organ systems of the body is an essential foundation for the study of pathophysiology; To understand pathophysiology, the student must also use principle, concepts and knowledge from the other field of study, including genetics,immunology and epidemiology. Pathophysiology is a science to study the mechanism of diseases. It focuses on the functional and metabolic alterations in the host during the development of diseases, and incorporates basic, translational and clinical research to advance understandings of disease and dysfunction. Pathophysiology is a rational subject in medical education and serves as a link between basic medicine and clinical medicine. For example 2 Development history of pathophysioogy (1) Morgagni(1682-1771):Organ Pathology (2) Virchow(1821-1902): Cellular Pathology (3) Bernard (1813-1878): Experimental pathology (4) 1879, Pathophysioloy