间氨基苯乙炔的合成工艺研究.docVIP

医药中间体间氨基苯乙炔的合成工艺研究 邵太丽 (皖南医学院药学系,安徽芜湖，241002) 摘要 目的：在查阅文献和试验的基础上，确定了间氨基苯乙炔的合成路线并进行工艺考察；方法：以间溴苯胺和丁炔醇为起始原料，经两步反应得目标产物；结果：该路线总收率为42%中间体及目标物结构均经H1-NMR确定ntermediate 3-Amionphenylacetylene Abstract Shao Tai-li （annan Medical College, Department of Pharmacy,Anhui ,Wuhu,241002） Abstract Aim：this paper，on the basis of literature and experiments，choosing a synthetic route of 3-aminophenylacet-ylene and optimizing the chosen route; Method：Using 3-bromoanilinc and 2-methyl-3-butyn-2-ol as the raw materials，obtaining 3-aminophenylacetylene through two steps.Result(s):The total yield is 42.3%，3-aminophen