碳亲核试剂与氮杂环丙烷开环反应的研究进展.pdfVIP

12 2011 39 8 , , , , (太原理工大学化学化工学院, 山西 太原 030024) : , , : ; ; ; The Research Progress in the R ing Opening ofAziridines w ith Various Carbon Nucleophiles LI Yan - w e,i SU J i- j uan, CHAN G H ong - hong, L I X ing, WEI W en - long ( College of Chem istry and Chem ical Engineering, T aiyuan Un i ersity of Technology, Shanx iTaiyuan 030024, Ch ina) Abstract: A s one of the most mi portant heterocyclic compounds, the r ing open ing of the azirid ines w ere attractted much attention of organic chem ists. The research progress in the ring opening of azirid ines w ith arious carbon nucleo philes during recent years w as summarized. M ostm entioned syntheticmethods had the ad antages ofm ild reaction condi tions, easy operation, good regioselecti ity and h igh y ields. K ey words: carbon nucleophiles; azirid ines; ring opening; re iew , 68% ~ 92% , , Lensink [ 1- 3] C. [ 14] ( Schem e 2) , , , [ 4] [ 5] [ 6] [ 7] [8] [9] , , 1 Schem e 1 [ 10] , [ 11] , 1985 E is M. J. , , 1989 [ 12] Baldw in J. E. Schem e 2 , C- C 2 [ 13] 1993 Osborn H. M. I. [ 15] ( Schem e 1), , 2004 D ing C. H. - 23 , 1 eq, 1~ 3 h ( Schem e 3), - 78 , 0. 9 eq 1~ 3 h, , 96%