增龄是影响健康人臂踝脉搏波速度的主要因素_临床医学论文.docVIP

增龄是影响健康人臂踝脉搏波速度的主要因素_临床医学论文 增龄是影响健康人臂踝脉搏波速度的主要因素_临床医学论文 作者：周红瑜 白小涓 吴兵 于凯 张伟光 韩璐璐 陈香美 【摘要】 目的 探讨健康人群臂踝脉搏波速度（baPWV）和踝臂指数（ABI）作为反映血管功能状态的指标随增龄变化的规律。方法 以沈阳地区健康人群为基础的横断面研究，按性别分为男性和女性两组；年龄每10岁分为一组：44岁及以下、45～54岁、55～64岁、65～74岁、75岁及以上共5组，总计400人。检测血脂、血糖等生化指标；颈动脉超声检测颈总动脉内膜中膜厚度、双侧颈总动脉血流参数等指标；动脉硬化检测仪检测四肢血压（包括收缩压、平均动脉压、舒张压、脉压差）、baPWV和ABI等指标。结果 各年龄组间baPWV存在显著差异（0.05）,随增龄baPWV变快，≤44岁年龄组和45～54岁年龄组baPWV值男性显著高于女性（0.05）;不同性别各年龄组间ABI值均无显著差异。相关分析显示年龄与baPWV具有显著相关性（r=0.732,0.01）；而baPWV与收缩压、脉压差、舒张压、颈动脉内膜中膜厚度、颈总动脉内径、收缩期峰值血流速度、颈动脉舒张期末血流速度亦显著相关（r分别为0.697、0.655、0.463、0.537、0.502、-0.277、-0.372，均P＜0.01）；baPWV与低密度脂蛋白、空腹血糖、总胆固醇、总甘油三酯的r值分别为0.176、0.163、0.125、0.099(均P＜0.05)。结论 年龄是影响健康人动脉僵硬度最主要的因素，baPWV可以反映随增龄动脉结构和功能的改变，可以有效评估健康人群血管健康状态。 【关键词】 血管衰老；健康人群；臂踝脉搏波速度；踝臂指数；增龄 【Abstract】 Objective To explore the changes of brachialankle pulse wave velocity(baPWV) and anklebrachial index(ABI) with aging in healthy people,and to analyze the law of vascular aging.Methods 400 healthy people were divided into≤44 years old,45～54 years old,55～64 years old,65～74 years old and ≥75 years old groups. The items including carotid ultrasonograph,biochemistry,blood pressure, baPWV and ABI were measured to observe their changes with aging.Results The changes of baPWV were significantly changed with aging ,and there were significant differences between men and women of≤44 years old group and 45～54 years old group.Age,systolic blood pressure(SBP),pulse pressure（PP）, diastolic blood pressrue(DBP),carotid artery intima(SPV), carotid artery enddiastolic velocity(EDV), low density lipoprotein(LDL),fast blood glucose,total cholesterol(TC),trigalloylglycerol(TG) were correlated with baPWV significantly(r value ＝ 0.732,0.697,0.655,0.463,0.537,0.502, -0.277,-0.372,0.176,0.163,0.125,0.099, respectively，all P＜0.01,except TC,TG P＜0.05).Conclusions Age is the most important factor of arterial stiffness of healthy people,LDL is the risk factor of arteriosclerosis. To combine with PWV and ABI can provide an evidence for evaluating heal