树突状细胞生物学研究进展.pdfVIP

# 1074# 中国实验血液学杂志 JournalofExpermi entalHematology 2010; 18(4): 1074- 1078 ( A r t ic le ID ): 1009- 2137( 2010) 04- 1074- 05 # 综述# 袁婷婷, 刘艳荣 北京大学人民医院北京大学血液病研究所,北京 100044 树突状细胞 (dendritic cells, DC)作为体内功能最强的抗原呈递细胞 (antigen presenting cells, APC), 其强 大的抗肿瘤效应以及 DC疫苗引领的肿瘤免疫治疗已经得到广泛认可。然而, 越来越多的研究表明, DC是一个 异质性极大的细胞群体,不同DC亚群的生物学特点存在较大差异。另外, DC疫苗的临床应用也证实除了按照人 们的意愿发挥保护性免疫功能外, DC疫苗还可引发 自身免疫耐受以及超敏反应等副作用。因此, 我们有必要对 DC亚群的生物学特点进行深入研究, 这对 DC疫苗的优化以及合理临床应用有重要指导意义。本文综述了DC亚 群的起源、分化及其免疫功能和临床应用方面的研究进展。 树突状细胞亚群;生物学特点; DC疫苗; 肿瘤免疫治疗 R730. 3; R730. 51 A Pr ogr ess in B iology of D endr it ic C ells) ) ) Review UAN Ting2Ting, LIU an2Rong Institute ofHematology, PekingUniversityP eopleHospital, Beijing 100044, China CorrespondingAuthor: LIU an2Rong, Senior ScientificResearcher, Professor. Tel: (010) E2mail: yrliu@ 163. com Ab str a c t As the m ost potent antigen2presenting cells (APC), dendritic cells are mi portant in launching both humoral and celluar mi mune responses against tum or. A lthough the high evaluation ofDC in mi mnunotherapy for cancer bymeans ofDC vaccines, more studies have indicatedDC isa heterogeneouspopulation and proved thatDC subsets are prom inentdeterm inants for the effectiveness of mi mune responses. D ifferentDC subsets display different receptors and surfacemolecules, and expressdifferent setsof cytokines/chem okines, which result in distinct mi m unologicaloutcom es. C linical trialswithex vivo generated DC vaccines alsom anifest unexpected mi m unological tolerance as well as allegic response. It is essential to study the biological aspects ofhumanDC subsets, which may be a key to the generation of novelDC2based vaccines. In this