类风湿关节炎血液学改变机制的研究进展.pdfVIP

2006 2 12 4 Medical Recapitulate,February 2006, Vol.12,No.4 ! 205 ! 王 亮( ) , 卓光生( ) (, 350004) :R593.22 :A :2006) : 类风湿关节炎是一种常见的自身免疫性疾病, 其血液系统的损害很常见慢性病贫血较 IL1b 多见, 其原因与肿瘤坏死因子(TNF) 干扰素(THF) 白细胞介素1(IL1) 白细胞介素6 , IFN (IL6) 等细胞因子抑制红系祖细胞的增殖分化及造成促红细胞生成素对贫血的钝性反应, 特别是IL6 , TNF 等造成铁的利用障碍有关; 中性粒细胞减少在Feltys 综合征(FS) 最为常见,研究表明与自身免疫失 IL1b CFUE 常有关; 另外, 血小板增多在类风湿关节炎中常见, 尤其在疾病处于活动时, 经大量研究表明与多种 细胞因子有关随着研究的不断进展, 对类风湿关节炎血液学改变机制的认识亦将趋于完善 : 类风湿关节炎; 慢性病; 贫血; 中性粒细胞减少; 血小板增多 1(MIP1) RA The Development about the Mechanisms of Hematological Change in Rheumatoid Arthritis WANG Liang , ZH UO Guangsheng. ( Dep artment of Hematology , The First Aff iliated H osp ital of Fuj ian Medi al University , , Fuzhou 350001, China) , Abstract: Rheu atoid arthritis (RA) is a co on autoi unedisease. The injury of its he atological syste , is ost co on, especially chronic ane ia.It isjust theeffect of cytokines, such as tu or necrosisfactora (TNF ) interferon(IFN) interleukin1(IL1) and interleukin6(IL6) ,which can inhibit the proliferation and dif ACD ferentiation of erythroid progenitor and blunt the response of erythropoietin to ane ia, especially the hypoferre ia [4] induced by interleukin6.Neutropenia can often be found in Feltys syndro e,which isrelative to the disorder of autoi unity.Inaddition,thro bocytosis i