天麻舒心颗粒对自发性高血压大鼠血压及颈动脉重构的影响.pdfVIP

) 666 ) CHINESE JOURNAL OF INT EGRAT IVE MEDICINE ON CARDIO-/ CEREBROV ASCU LAR DISEASE June 2009 Vo1. 7 No. 6 # / # 1) 王 洋, 徐贵成, 李多娇, 郑 军 : 探讨天麻舒心颗粒降压及改善颈动脉重构的疗效 50 只自发性高血压大鼠( SH R) 随机 成天麻舒心大 中小剂量组及阳性对照组模型对照组, 10 只Wistar 大鼠为正常对照组, 别给予不同剂量的天麻舒心浸膏液卡托普利片蒸馏 水2 周测量1 次鼠尾动脉收缩压; 3 个月后, 观察每组左颈总动脉内- 中膜厚度( IMT) 腔径IMT/ 腔径及血浆肾素活性( PRA) 血 管紧张素Ò (AngÒ ) 给药12 周后, 与模型对照组比较, 各给药组SH R 左颈动脉 IMTPRAAng Ò 均显著降低( P 0. 01 或P 0.001) 随着鼠龄的增加, 天麻舒心各组血压虽有所上升, 但上升的幅度明显低于模型对照组 天麻舒心颗粒治疗高 血压病确实有效, 而且能通过改善动脉重构, 减轻甚至逆转高血压靶器官损害 : 天麻舒心颗粒; 高血压病;颈动脉重构 : R544. 1 R2 9. 5 :A : 1672- 1349(2009) 06-0666-03 The Influence Effect of Tianmashuxin Granule on Blood Pressure and Carotid Artery Vascular Remodeling in Spontaneous Hypertensi e Rats Wang Yang, Xu Guicheng, Li Duojiao, et al Guang. anmen Hospital, China Academy of Chinese Medical Sciences( Beijing 100053) Abstract: Objecti e To invest igat e the effect of Tianmashuxin granule on blood pressure ( BP) and carotid art ery vascular re- modeling in the spontaneous hypertensive rats ( SH R) .Methods Fifty SH R w ere randomly divided into five groups: Tianmashuxin granule group ( low dosage, medium dosage and high dosage group) treated w ith Tianmashuxin granule extract, positive control group and model group treated w ith captopril and distilled w ater, respect ively. The systolic caudal arterial pressure fortnightly and the left carotid artery intima-media thickness ( IMT ) , lumen diameter, int ima-media thickness/ lumen diameter, plasma renin activity ( PRA) and angiotensin ( AngÒ ) w ere measured at the end of t he third mont h. Results Compared with the model group, the left carotid artery intima-media thickness, level of PRA and AngÒ in Tianmashuxin granule group and posit