糖尿病视网膜病变的药物干预.pdfVIP

254 2009, Vol. 33, N o. 6 2009年第33卷 第6期 第254页 Prog ress in Pharma ceu tica l Sciences do:i 10. 3969/ . issn. 100 1- 5094. 2009. 06. 003 糖尿病视网膜病变的药物干预 1, 2 2* 陈 放 , 张洪泉 ( 1. 扬州大学临床医学院眼科, 江苏扬州 225001, 2. 扬州大学医药研究所, 江苏扬州 225001) [ ] , , , C [ ] ; ; [ ] R 977; R5 871 [] A [] 1001- 5094 ( 2009) 06- 0254 - 06 D rug Intervention for D iabetic Retinopathy 1, 2 2 CHEN F ang , ZHANG H ongquan (1. D epartm ent of Op thalmology, M edical School, Yangzhou University, Yangzhou 22 001, China; 2. M edi cal and P harmaceutical Institute, Yangzhou University, Yangzhou 22 001, Ch ina) Ab stract] T he pathogenesis of d iabe tic ret inopathy w as briefly introduced. A nd the therap ies w hich have been deve loped at present, including aldose reductase inhibitor, advanced g lycat ion end products inh ib ito r, pro te in kinase C inhibitor, vascular endo the lia l grow th factor inh ib itor, antiox idants, and cortico stero ids w ere rev iew ed. D iabetic retinopathy, the common com p lication o f d iabetesm ellitu s, is the leading cause o f blindness. Researchers have d irected their efforts tow ards better understanding of the specific b io log ica l and chem ical changes occurring in d iabet ic retinopathy to deve lop m ore targeted drug intervention and treatm ent strateg ies. Key w ord s] diabetic retinopathy; pathogenesis; drug intervention ( diabetic re tinopathy, DR ) DR , DR 1 , DR