Relationship of Serum Interleukin-18 and Interleukin-12 Levels with Clinicopathology in Renal Cell Carcinoma.pdfVIP

Relationship of Serum Interleukin-18 and Interleukin-12 Levels with Clinicopathology in Renal Cell Carcinoma.pdf

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Relationship of Serum Interleukin-18 and Interleukin-12 Levels with Clinicopathology in Renal Cell Carcinoma.pdf

维普资讯 304 www . springerlink.com/ChinesejournalofCancerResearchl9{4):3O4_一3o8,2007 RelationshipofSerum Interleukin-18andInterleukin-12Levelswith Clinic0path0l0gyinRenalCellCarcinoma NONGShao-jun(农绍军), WENDuan—gai(~端改), FANCai—bin(樊彩斌), OUYANGJun(欧阳骏) DepartmentofUrology,TheF stAffiliatedHospital,SoochowUniversity,Suzhou215006 CLCnumber:R737.11 Documentcode:A ArticleID:1000-9604(2007)-04-05-0304 ABSTRACT objective:Toinvestigatetherelationshipbetweenseruminterleukin.18andinter1eukin.12levelsandclinicopathologv ofrenalcellcarcinoma.Methods:Peripheralbloodsampleswereobtainedfrom 20healthyvolunteersand60patientswith renalcellcracinomabeforecurativesurgery.IL-12andIL一18levelsweredeterminedbyenzyme.1inkedimmunosorbentassay. Results:Meanserum IL-12andIL一18levelsweresignificantlyhigherinpatientswithrenal cellcracinomacompraedwith healthyvolunteers(P0.05)andmeanserum IL一12andIL一18levelsincreasedinpatientsasthepathologicstageprogressed. Apositivecorrelationwasobservedbetweenserum IL-12nadIL一18levels(P0.05).Inpatientswithrenalcellcracinoma. increasingserum IL 12andIL 18levelscorrelatedwithpathologicalstageandFuhrmangrade.Conclusion:Serum IL一12and IL一18mi ghtbeusefultumormarkersinpatientswithrenalcellcarcinoma. Keywords:Interleukin-·18;Interleukin-12;Renalcellcarcinoma A recently discovered cytokine.interleukin一18. n rIENTSAND M ETHoDS hasmany functionalproperties similarto those of interleukin一12. It is produced by activated Patients macrophages and dendritic cells, and plays an importantroleintheTh1response.basedprimarilyon A totalof67patientswithunilateralrenalmasses itsabilityto induceIFN—vproductionbyT cellsand suspiciousofRCCbymeansofcomputedtomography NK cellslJJ.IL一18inducesproliferationofactivatedT or magnetic

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