万可松在心肺脑复苏早期应用临床意义.pdfVIP

万可松在心肺脑复苏早期应用的临床意义 蹇华胜 于长青 沈康强 彭博 汤轶姝 [摘要] 目的 探讨万可松在心肺脑复苏早期应用的临床意义。 方法 呼吸心脏骤停患 者 85 例，随机分为治疗组和对照组（治疗组 44 例，对照组 41 例），治疗组自主呼吸恢复初 期，脉搏氧饱和度（SpO2 ）持续下降达 95% 以下，呼吸机对抗且排除其它原因所致的缺氧 时，立即静脉注射万可松 0.1mg/kg 。对照组呼吸机对抗，SpO2 持续下降达 85% 以下时，静 脉注射万可松 0.1mg/kg 。观察 SpO2 、抽搐或癫痫持续状态变化和 24h 存活率。 结果 治 疗组 44 例，24h 存活 26 例，死亡 18 例，24h 存活率 59.1% 。对照组41 例，24h 存活 19 例， 死亡 22 例，24h 存活率 46.3% 。治疗组24h 存活率明显高于对照组（p0.01）。结论 心肺 脑复苏早期应用万可松可提高呼吸心脏骤停 24h 存活率，有一定的临床推广价值。 [关键词] 万可松 机械通气 复苏 Effects of vecuronium in patients during cardiopulmonary cerebral resuscitation JIAN Hua-sheng, YU Chang-qing, SHEN Kang-qiang, PENG BO, TANG Yi-shu. Emergency Department, Daping Hospital ，Third Military Medical University, Chongqing 400042, China [Abstract] Objective To study the effect of vecurinium in patients during cardiopulmonary cerebral resuscitation(CPCR),when it was used early. Methods The patients with cardiac arrest were divided into 2 groups,treated group(44 cases) and control group(41 cases). The vecuronuum(0.1mg/kg) was injected in treated group,as soon as SpO2 was less than 95% during no synchronism ventilation. In control group,it was done after SpO 85%. The change of SpO , effect of treatment 2 2 on anoxia with refractory status pilepticus and the survival rate at 24 hour were observed during CPCR. Result SpO2 gradually incueased to normal in 83case patients within 2-6min and in another 2 case patients with drowning 40 min later. Tic in all patients was under control. The survival rate at 24 hour is 59.1% in treated group. It is 46.3% in control group. Conclusion Vecurnium may improve anoxia induced by no synchronism ventilation and be a effective thera