青年人生理性十二指肠胃反流.docVIP

世界华人消化杂志 2008年10月28日;16(30): 3451-3453 临床经验 CLINICAL PRACTICE 青年人生理性十二指肠胃反流的相关因素 陈维顺, 罗虹雨, 朱宜人, 钟燎原, 周红兵, 张选均, 湖南省株洲市一医院(中南大学株洲临床学院) 湖南省株洲市 412000作者贡献分布: 课题设计由陈维顺与罗虹雨完成; 研究过程由朱宜人、钟燎原及周红兵完成; 数据分析及论文撰写由陈维顺完成; 张选均进行指导.通讯作者: 陈维顺, 412000, 湖南省株洲市, 湖南省株洲市一医院(中南大学株洲临床学院)消化内科. chen8242123@电话: 0733-8203211收稿日期: 2008-08-17 修回日期: 2008-09-26接受日期: 2008-10-07 在线出版日期: 2008-10-28Physiological duodenogastric reflux in young healthy adults Wei-Shun Chen, Hong-Yu Luo, Yi-Ren Zhu, Liao-Yuan Zhong, Hong-Bing Zhou, Xuan-Jun ZhangWei-Shun Chen, Hong-Yu Luo, Yi-Ren Zhu, Liao-Yuan Zhong, Hong-Bing Zhou, Xuan-Jun Zhang, Department of Gastroenterology, the First Hospital of Zhuzhou city (Zhuzhou Hospital of Central South University), Zhuzhou 412000, Hunan Province, China Correspondence to: Wei-Shun Chen, Department of Gastroenterology, the First Hospital of Zhuzhou city (Zhuzhou Hospital of Central South University), Zhuzhou 412000, Hunan Province, China. chen8242123@Received: 2008-08-17 Revised: 2008-09-26 Accepted: 2008-10-07 Published online: 2008-10-28AbstractAIM: To investigate the characteristics of physiological duodenogastric reflux (DGR) in young healthy adults, and to study the relationship between DGR and pathologically altered gastric mucosa.METHODS: Twenty healthy young volunteers received the conventional endoscopy, 24 h dynamic stomach pH and bile reflux monitoring, HE staining routine pathological examination as well as improved chromatin Giemsa line inspection for H pylori.RESULTS: Of 20 cases, two subjects had bile reflux, 6 had H pylori positive tests and the rest showed normal gastric mucosa or mild antral gastritis. No ulceration, erosions, atrophy or intestinal metaplasia were observed in all subjects (including 6 Helicobacter pylori infection) on endoscopic and histological findings. All subjects were found to have bile reflux at variable degrees (gastric bilirubin absorbance 0.14) and total period of bile reflux (abs0.14) was 12.5% ± 8.8%. Of all