玉丹荣心丸抗急性病毒性心肌炎的实验研究.pdfVIP

齐齐哈尔医学院学报 2007 年第 28 卷第 5 期 ·52 1 · 玉丹荣心丸抗急性病毒性心肌炎的实验研究 赵 　晶　张中海 　刘 　剑 　孙 　艳 　钟照华 ( ) 【摘要】　目的　观察中成药玉丹荣心丸对 B 组柯萨奇病毒 CVB 感染 Balb/ c 小鼠所致急性病毒 性心肌炎的治疗效果的研究 。方法 　Balb/ c 鼠腹腔接种 1000 TCID50/ 0 . 1ml CVB ,经过两周的持续注 射成功获得急性病毒性心肌炎的动物模型 。将动物随机分为病毒对照组 、药物组 ,药物组使用中成药玉 丹荣心丸进行灌胃给药 ,而病毒对照组不使用任何药物 ,28 天后观察小鼠心肌组织的病理改变 。结果 　药物组小鼠心肌组织的病理改变轻微 ,并有好转迹象 ,而病毒对照组病理改变严重 ,有死亡 。结论 　 玉丹荣心丸对 B 组柯萨奇病毒感染所致的急性病毒性心肌炎有很强的治疗效果 。 【关键词】　玉丹荣心丸　病毒性心肌炎 　B 组柯萨奇病毒 　小鼠 Experimental Therapy of Acute Coxsackie Viral Myocarditis by Chinese Traditional Medicine - Yudan Rongxing Pill 　 Zhao J i n , et al . 　 ( Dep art ment of L ab Test , Daqing People ’s Ho spit al , Hei longj iang 1633 16 China) 【Abstract 】　Objective 　To Ob serve t he t herap eutic effect s of Yudan Rrongxing Pill ( YDRXP) ,t he Chinese t raditional medicine ,again st t he acut e myocar diti s in Balb/ c mice cau sed by Co xsackie viru s B . Methods 　An acut e viral myocar diti s Balb/ c model wa s p rep ared by inoculating 100 TCID50/ 0 . 1ml of CVB3m for 2 week s. The infect ed mice were t hen randomly divided into t hree group s :normal cont rol ,vi ral cont rol ,and YDRXW - t reat ed . The YDRXP - t reat ed group were orally given YDRXP . The viral con t rol gave viru s only . The myocar dial p at holo gy was ob served aft er 28 days. Results 　The viral cont rol mice could be found p at hologically bad inj ured and dead , while t he p at holo gical manifest ation s in t he YDRXP - t reat ed mice were mild and suggest ed recovery t rends. Conclusions 　Traditional Chinese medi cine YDRXP can conduct a t herap eutic effect to acut e viral myocar diti s cau sed by CVB . 【Key words】　TCM - Yudan Rongxing Pill 　Viral myocar diti s 　Cox sackie viru s B 　Mice 　　病毒