奥氮平与氯丙嗪治疗以阳性症状为主的精神分裂症对照研究.pdfVIP

140 四川精神卫生 2008年第 21卷第 3期 奥氮平与氯丙嗪治疗以阳性症状为主 的精神分裂症对照研究 谢传革 李秀玲 刘庆海 = 比较奥氮平与氯丙嗪治疗以阳性症状为主的精神分裂症的疗效及安全性。 将 126例精 神分裂症患 随机分为奥氮平组和氯丙嗪组, 共治疗 8周。用临床疗效和阳性症状量表 ( SAPS)评定疗效, 用不良 2 反应量表( TESS)评定不良反应。 奥氮平组痊愈率明显高于氯丙嗪组(V = 41 91, P 0105) ;且起效明显较氯 丙嗪组快( t= 21 46, P 0105) ; 不良反应发生率和严重程度均较氯丙嗪组低而轻, 亦有显著性差异 (P 0105)。 奥氮平对以阳性症状为主的精神分裂症疗效较好, 起效快, 不良反应少而轻。 = 奥氮平 氯丙嗪 精神分裂症 阳性症状 = R74913 = A = 1007- 3256 ( 2008) 03- 0140- 03 A con trol stu dy of olan za p in e an d ch lorpr om az in e to tr ea te th e p o sit iv e sym p tom s of sch izophr en ia1X IE Chu ange, LI X iu ling, LIU Qingha i. J in ing M enta lH osp ita l, Sha ndong 272051, Ch ina = Ab stra ct O bj ect ive To compare t e clin ical efficacy and t e side- efficacy between olanzap ine and c lorprom a2 zine to treat sc izop ren ia wit t e positive symptom s. . M eth od s 108 cases sc izop reniaw it t e positive symptom swas random ly d ivided into olanzap ine group and c lorprom azine group. T e course of treamt entwas 8weeks. T e clin ical efficacy and SAPS were evaluated t e efficacy. TESS was evaluated t e side- efficacy. R esu lt s T e recovery raet of olanzapine were evidence ig . O lanzapine group gettingup effect ad faster in onset of efficiency. T e side effects of olanzapine group were fewer occur rate and slig ter severity exlent. C on c lu sion s O lanzapine treatment sc izop ren ia wit t e positive symp2 tom s ave preferably efficacy, getting up affect faster, t e side effects fewer and slig ter. = K ey w or d s O lanzap ine C lorprom azine Sc izop renia Positive symptom