紫草素及其衍生物的抗肿瘤作用.pdfVIP

2005 1 12 1 CH IN J CAN CER PREV TR EAT, January 2005, V o .l 12 N o. 1 # 75# 综述# 讲座 黄河, 刘宗潮 中山大学肿瘤防治中心实验研究部, 广东 广州 510060 A ntitumor e ffect o f sh ikon in and its de riva tives H UAN G H e, LIU Zong-chao Research D ep artm ent, Cancer Cen ter, Sun Ya t-sen University, Guang hou 510060, P. R. Ch ina = 紫草为传统的中药, 紫草的化学 [ AB STRA CT ] L ithosp ermum ery throrhi on S ieb. et Zucc. is a trad -i 成份复杂, 具有广泛的药理作用, 抗肿瘤 tional Ch inese m ed icine, w h ich h as comp le te chem ica l composition and 作用是其中 一天然紫草素类化合物 w ide pha rm aco logy e ffects. An titum or effect is one o f the ph arm aco logy 由于抗瘤作用弱, 仍未用于临床为了减 effect s. N a tura l shikonin- like compounds are not used in c linic becau se 少它们的毒副反应和增强抗肿瘤作用, 人 o f h av ing e ither w eak antitumo r effect o r strong tox ic ity. In o rder to de- 们半合成了许多紫草素类衍生物实验 crease their tox ic ity and increase the ability o f antitumo r effect, m any 证明, 天然紫草素类化合物及其衍生物具 shikonin- like der ivatives have been syn thesized artif ic ia lly. Exp ermi ents 有不同程度的细胞毒作用和抗肿瘤作用 prov ed tha t natura l sh ikon in- like compounds and the ir der ivatives pos- 初步的作用机制研究表明, 紫草素类化合 sessed cytotox icity and antitum or effect. P r mi a ry stu dies o f m ech an ism on 物及其衍生物能诱导肿瘤细胞凋亡, 激活 antitum or effec t presented th at natural sh ikon in- like com pounds and the ir 促细胞分裂原