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Acta Physiologica Sinica, October 25, 2005, 57 (5): 587-592 587
Wistar-Kyoto
*
310003
(angiotensin Ang )(spontaneously hypertensive ratSHR)Wistar-
Kyoto (WKY)(vascular smooth muscle cells, VSMCs)(extracellular signal-regulated pro-
5
tein kinases ERKs) SHR WKY VSMCs 1×10 mmol/L
1×105 mmol/L PD98059 1×107 mmol/L Ang 24 h
VSMCs ERK Western-blot ERK (total ERK t-ERK)ERK
(phosphorylated-ERKp-ERK)-1 (mitogen-activated protein kinases phosphatase-1, MKP-1)
RT-PCR MKP-1 mRNA (1) SHR WKY Ang VSMCs ERK
p-ERK MKP-1 MKP-1 mRNA (P 0.05); SHR WKY Ang Ang
+PD98059 (2) SHR VSMCs ERK p-ERKMKP-1 MKP-1
mRNA WKY (P0.01) (3) SHR WKY Ang Ang +
Ang +PD98059 VSMCs t-ERK Ang 1 (Ang
type 1 AT 1)SHR WKY VSMCs ERK ERK p-ERK MKP-1
MKP-1 mRNA
Q254; R544.1
Effects of angiotensin on extracellular signal-regulated protein kinases
signaling pathway in cultured vascular smooth muscle cells from Wistar-Kyoto
rats and spontaneously hypertensive rats
*
ZHU Jian-Hua, LIU Zhong, HUANG Zhao-Yang , LI Shan
Department of Cardiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
Abstract: The aim of this study was to investigate the effects of angiotensin (Ang ) on extracellular signal-regulated protein kinase
(ERK) signaling pathway in cultured vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) and Wistar-
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