氧化应激与肝脏损伤.docVIP

氧化应激与肝脏损伤 吴 娜, 蔡光明, 何 群 吴娜, 湖南中医药大学 湖南省长沙市 410208吴娜, 蔡光明, 中国人民解放军302医院中药研究所 北京市 100039何群, 湖南中医药大学药剂教研室 湖南省长沙市 410208作者贡献分布: 本文选题, 参考文献检索及撰写由吴娜完成; 论文修改由蔡光明与何群完成. 通讯作者: 蔡光明, 100039, 北京市, 中国人民解放军302医院中药研究所. cgm1004@电话: 010收稿日期: 2008-08-14 修回日期: 2008-09-21接受日期: 2008-09-22 在线出版日期: 2008-10-18Oxidative stress and hepatic injuryNa Wu, Guang-Ming Cai, Qun HeNa Wu,Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaNa Wu, Guang-Ming Cai,Institute of Chinese Materia Medica, the 302th Hospital of Chinese PLA, Beijing 100039, ChinaQun He, Pharmaceutical Division, Hunan University of Traditional Chinese Medicine, Changsha 410208, Hunan Province, ChinaCorrespondence to:Guang-Ming Cai, Institute of Chinese Materia Medica, the 302th Hospital of Chinese PLA, Beijing 100039, China. cgm1004@Received: 2008-08-14 Revised: 2008-09-21Accepted:2008-09-22 Published online: 2008-10-18AbstractOxidative stress, initiated by reactive oxygen species, is the collective pathophysiological mechanism of many hepatopathies. Oxidative stress results in hepatic injury mainly by priming lipid peroxidation to change the function of biological membrane, covalent immobilization of biomacromolecules and destroying the enzyme activity considering cytokine (TNF-α and NF-κB) interaction. The role of oxidative stress in many hepatopathies such as fatty liver desease, viral hepatitis, hepatic fibrosis is innegligible. Key Words: Oxidative stress; Reactive oxygen species; Hepatic injury; Lipid peroxidation; CytokineWu N, Cai GM, He Q. Oxidative stress and hepatic injury. Shijie Huaren Xiaohua Zazhi 2008; 16(29): 3310-3315摘要活性氧自由基引发的氧化应激是多种肝病发病的共同病理生理基础. 氧化应激主要通过启动膜脂质过氧化改变生物膜功能、与生物大分子共价结合及破坏酶的活性等在细胞因子(如TNF-α、NF-κB)的共同作用下引起不同程度的肝损伤. 氧化应激在脂肪肝、病毒性肝炎、肝纤维化等肝病中可产生不容忽视的作用.?关键词: 氧化应激; 活性氧; 肝损伤; 脂质过氧化; 细胞因子吴娜, 蔡光明, 何群. 氧化应激与肝脏损伤.?世界华人消化杂志 2008; 16(29): 3310-3315/1009-3079/16/3310.asp0 引言胃生物体内的能量代谢将氧气作为有氧代谢过程中的电子接受体, 不可避免地产生活性氧(reactive oxygen species,