丁酸氯维地平注射乳的药理及临床研究.pdfVIP

Ch inese Jou rnal of N ew D rugs 20 10 , 19 ( 12) ·新药述评 · 丁酸氯维地平注射乳的药理及临床研究 1, 2 1 2 李 　灵 ,毕开顺 ,胡 　欣 ( 1沈阳药科大学药学院 , 沈阳 1100 16; 2 卫生部北京医院药剂科 ,北京 100730) 　　[摘要 ] 　静脉注射用乳剂丁酸氯维地平能快速 、精确地控制血压 , 适用于不宜口服治疗或口服治疗无 效的高血压患者 。由于药效短和较好的风险利益关系 ,该药已成为抗高血压治疗的新选择 。现对其药理作 用 、临床研究及不良反应等做一综述 。 [关键词 ] 　丁酸氯维地平 ;高血压 ; 药理作用 ;临床研究 [中图分类号 ] R972. 4　　[文献标志码 ] A 　　[文章编号 ] 1003 - 3734 (20 10) 12 - 1003 - 04 Pharm acology and clin ica l stud ies of clev id ip ine butyra te injectable em ulsion 1, 2 1 2 L I L ing , B I Kaishun , HU X in ( 1 S chool of P ha rm acy, S heny ang P ha rm aceu tica l Un ivers ity, S heny ang 1100 16, Ch ina; 2 D ep a rtm en t of P ha rm acy, B eij ing H osp ita l, the M in is try of H ea lth, B eij ing 100730, Ch ina) [ A b stract] 　C levidip ine bu tyrate injectab le em u lsion can con tro l b lood p re ssu re qu ick ly and effectively. W hen oral drug therap y is not app rop riate for b lood p re ssu re con tro l, its rap id action and good benefittorisk p rofile m ay be a good alternative for an tihyp erten sive treatm en t. In th is article, the p harm aco logical effects, clin ical stud ie s and adverse drug reaction s of clevid ip ine bu tyrate injectab le em u lsion were summ arized. [ Key words] 　clevid ip ine bu tyrate; hyp erten sion; p harm aco logical effect; clin ical study ) 　　急性高血压会直接或间接引起外科手术患者术 tyrate,商品名 : C levip rex 于 2008年 8月 1 日经美