利用PLS_VIP方法筛选差异表达基因_英文_韩放.pdfVIP

( ) , 45 , 1 , 2009 1 Acta Scientiarum Naturalium Universitatis Pekinensis, Vol.45, No. 1 (Jan. 2009) Searching for Differentially Expressed Genes by PLS-VIP Method 1 1 1 1,2, ­ HAN Fang , WU Jingchen , XU Jiangfeng , DENG Minghua 11 School of Mathematical Science, Peking University, Beijing 100871; 21 Center for Theoretical Biology, Peking University, Beijing 100871; ­ Corresponding Author, E-mail: dengmh@math.pku. edu. cn Abstract A new approach called PLS-VIP based on variablesp importance of projection ( VIP) for detecting differentially expressed genes is proposed. It is a new method to sum up the contribution of components based on Partial Least Square method ( PLS) . As it takes the correlation of different genes into consideration, it is more suitable than those classification methods based on reviewing distinct genes separately. The effect of genes extracted by ordinary PLS, discriminant PLS and proposed method to classify multi-class tumors is compared. Results show that the error rate of the new method is obviously lower than the other two methods in most cases. Key words microarray; differentially expressed genes; reduction of dimension; PLS-VIP PLS-VIP 1 1 1 1, 2, ­ 韩放 吴晶辰 徐江峰 邓明华 11 , 100871; 21 , 100871; ­, E-mail: dengmh@ math. pku. edu. cn ( ) PLS , , PLS-VIP ; ; ; PLS-VIP O21 Microarrays have become increasingly common in ( DE ) are often referred to as clinical markers. biological and medical research. They enable the