女性肺腺癌CD44表达_DNA含量与凋亡率的相关性研究_薛晓霞.pdfVIP

2007 10 10 5 　Chin J Lu ng Cancer, Octob er 2007, Vol. 10, No. 5 381 CD44 、DNA 薛晓霞　张莹　蒋东华　何钦成　崔泽实　周宝森 【】　　CD44 , 。CD44 、DNA (DI)、(PI) 。　(FCM) 61 45 CD44 、DI、PI 。 　 DNA 75. 41%。CD44 、DI PI (P0. 01), (P0. 0 1)。 CD44 DI (P 0. 0 1), DI (P0. 01)。　CD44 、DNA 、 、。 【】　　　　　CD44 　　DNA　　 【】　R734. 2 Correlation among expression of CD44, DNA content and apoptosis in female adenocarcinoma of the lung　X UE X iaox ia, Z H A N G Ying, J I A N G Dong hua, HE Qincheng , CUI Z esh i, Z H OUB aosen. D ep ar m en of Ep -i dem iology , Ch ina Med ical Un ivers i y , Sheny ang, L iaon ing 11000 1, P . R . Ch ina Corresp ond ing au hor:Z H OU B aosen, E-ma il :bsz hou @ma il. cm u. edu. cn 【Abstract】　Background and objective　Cluster of differentiation 44 (CD44)is a famil of t ransmembrane gl coproteins. A s cell surface h aluronate receptor, it has been found to be widel expressed in a variet of cells. The aim of this stud is to assess the relationship among CD44 expression, DNA content, proliferation index (PI)and apoptosis in female adenocarcinoma of the lung . Methods　The expression of CD44, DNA in- dex (DI), PI and apoptotic rate were studied in 6 1 cases of female adenocarcinoma of the lung, paracancerous tissues and 45 cases of benign lesions b flow c tometr . Results 　The percent of DNA aneuploid w as 75. 41%in adenocarcinoma. The expression of CD44, DI and PI in adenocarcinoma were significantl higher than those in paracancerous and benign controls (P0. 01), however the apoptotic rate w as obviousl low er in adenocarcinoma than that in paracancerous and benign controls (P0. 01). There w as a positive correlation