电针治疗抑郁症的效果和多基因表达变化有关.docVIP

电针治疗抑郁症的效果与多基因表达变化有关 目前的研究还无法全面深入地阐明人类抑郁症多基因综合调控的复杂机制。利用基因芯片技术可系统深入地探讨慢性应激诱发抑郁大鼠脑神经基因谱表达的变化规律，以期微观上筛选出具有上调或下调的抑郁易感基因。中国解放军总医院段冬梅博士所在团队于《中国神经再生研究（英文版）》杂志2014年1月第1期发表的一项关于“Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints”的研究，以全基因组芯片检测方法证实电针刺激抑郁大鼠“百会”（DU20）EX-HN3）穴后，其海马组织中表达发生变化的Trim32等19种基因表达恢复至接近正常。提示电针治疗抑郁症与多基因表达变化有关。 Article: Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints, by Dongmei Duan1, Xiuyan Yang2, Tu Ya3, Liping Chen1 (1 Department of Traditional Chinese Medicine of South Building, Chinese PLA General Hospital, Beijing 100853, China; 2 Institute of Health Maintenance, Beijing University of Chinese Medicine, Beijing 100029, China; 3 School of Acupuncture and Moxibustion, Beijing University of Chinese Medicine, Beijing 100037, China) Duan DM, Yang XY, Ya T, Chen LP. Hippocampal gene expression in a rat model of depression after electroacupuncture at the Baihui and Yintang acupoints. Neural Regen Res. 2014;9(1):76-83. 欲获更多资讯：Neural Regen Reslectroacupuncture effect on depression and variation of polygenes expression Preliminary basic research and clinical findings have demonstrated that electroacupuncture therapy exhibits positive effects in ameliorating depression. However, most studies of the underlying mechanism are at the single gene level; there are few reports regarding the mechanism at the whole-genome level. Using a rat genomic gene-chip, Dr. Dongmei Duan and co-workers from General PLA Hospital in China profiled hippocampal gene expression changes in rats after electroacupuncture therapy. Electroacupuncture therapy alleviated depression-related manifestations in the model rats. Using gene-chip analysis, electroacupuncture at Baihui (DU20) and Yintang (EX-HN3) regulates the expression of 21 genes. Real-time PCR showed that the genes Vgf, Igf2, Tmp32, Loc500373, Hif1a, Folr1, Nmb, and Rtn were upregulated or downreg